AI Article Synopsis
- - SARS-CoV-2 primarily infects the respiratory tract, leading to COVID-19, with respiratory failure being the main cause of death, but other organs like the kidneys and heart can also be affected in severe cases.
- - An excessive inflammatory response and weakened antiviral defense are critical factors in how COVID-19 develops, often resulting in immunothrombosis, which is the formation of blood clots in both the lungs and other organs.
- - The review discusses the role of SARS-CoV-2 in lung inflammation and the potential benefits of vitamin D as a supplementary treatment during different stages of COVID-19.
Article Abstract
SARS-CoV-2 infects the respiratory tract and leads to the disease entity, COVID-19. Accordingly, the lungs bear the greatest pathologic burden with the major cause of death being respiratory failure. However, organs remote from the initial site of infection (e.g., kidney, heart) are not spared, particularly in severe and fatal cases. Emerging evidence indicates that an excessive inflammatory response coupled with a diminished antiviral defense is pivotal in the initiation and development of COVID-19. A common finding in autopsy specimens is the presence of thrombi in the lungs as well as remote organs, indicative of immunothrombosis. Herein, the role of SARS-CoV-2 in lung inflammation and associated sequelae are reviewed with an emphasis on immunothrombosis. In as much as vitamin D is touted as a supplement to conventional therapies of COVID-19, the impact of this vitamin at various junctures of COVID-19 pathogenesis is also addressed.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308422 | PMC |
| http://dx.doi.org/10.3390/nu13072216 | DOI Listing |
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