AI Article Synopsis
- Encapsulated bacteria like type b pose serious health risks for young children, even with vaccines available.
- Highly specific antibodies are crucial for protecting against serious infections caused by these bacteria.
- The review highlights the need for standardized tests to assess functional antibodies, which are essential for evaluating vaccine effectiveness and comparing clinical study results.
Article Abstract
Encapsulated bacteria such as , type b and cause significant morbidity and mortality in young children despite the availability of vaccines. Highly specific antibodies are the primary mechanism of protection against invasive disease. Robust and standardised assays that measure functional antibodies are also necessary for vaccine evaluation and allow for the accurate comparison of data between clinical studies. This mini review describes the current state of functional antibody assays and their importance in measuring protective immunity.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8234458 | PMC |
| http://dx.doi.org/10.3390/vaccines9060677 | DOI Listing |
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