(1) Background: Preterm-born children have an increased cardiovascular risk with the first clinical manifestation during childhood and/or adolescence. (2) Methods: The occurrence of overweight/obesity, prehypertension/hypertension, valve problems or heart defects, and postnatal microRNA expression profiles were examined in preterm-born children at the age of 3 to 11 years descending from preterm prelabor rupture of membranes (PPROM) and spontaneous preterm birth (PTB) pregnancies. The whole peripheral blood gene expression of 29 selected microRNAs associated with cardiovascular diseases was the subject of our interest. (3) Results: Nearly one-third of preterm-born children (32.43%) had valve problems and/or heart defects. The occurrence of systolic and diastolic prehypertension/hypertension was also inconsiderable in a group of preterm-born children (27.03% and 18.92%). The vast majority of children descending from either PPROM (85.45%) or PTB pregnancies (85.71%) had also significantly altered microRNA expression profiles at 90.0% specificity. (4) Conclusions: Postnatal microRNA expression profiles were significantly influenced by antenatal and early postnatal factors (gestational age at delivery, birth weight of newborns, and condition of newborns at the moment of birth). These findings may contribute to the explanation of increased cardiovascular risk in preterm-born children. These findings strongly support the belief that preterm-born children should be dispensarized for a long time to have access to specialized medical care.
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http://dx.doi.org/10.3390/biomedicines9070727 | DOI Listing |
Dev Cogn Neurosci
December 2024
Key Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China. Electronic address:
Although recent studies have consistently reported the emergence of resting-state networks in early infancy, the changes in inter-network functional connectivity with age are controversial and the alterations in its dynamics remain unclear at this stage. This study aimed to investigate dynamic functional network connectivity (dFNC) using resting-state functional MRI in 244 full-term (age: 37-44 weeks) and 36 preterm infants (age: 37-43 weeks) from the dHCP dataset. We evaluated whether early dFNC exhibits age-dependent changes and is influenced by preterm birth.
View Article and Find Full Text PDFJ Autism Dev Disord
December 2024
Research in Developmental Diversity Lab (RIDDL) UGent, Department of Experimental Clinical and Health Psychology, Ghent University, Henri Dunantlaan 2, 9000, Ghent, Belgium.
This longitudinal study investigated the predictive value of initial level and growth rate of joint attention and play from 10 to 24 months for language abilities of 24-month-old toddlers at elevated likelihood (EL) for autism. (Semi-)structured assessments were used to measure all variables at different timepoints prospectively in younger siblings of children with autism (siblings, n = 48) and children born before 30 gestational weeks (preterms, n = 49). A positive association was found between initial level of play at 10 months and expressive language at 24 months in siblings, but not in preterms.
View Article and Find Full Text PDFCurr Opin Clin Nutr Metab Care
January 2025
Amsterdam Reproduction & Development Research Institute, Amsterdam UMC.
Purpose Of Review: This review aims to evaluate the latest available evidence on the differences between human milk proteins versus infant formula proteins and its effects on growth and development in preterm infants.
Recent Findings: High protein intake supports initial growth in preterm infants, although the long-term benefits remain unclear. Human milk requires adequate fortification to meet nutritional needs of preterm born infants.
Arch Dis Child Fetal Neonatal Ed
December 2024
Department of Population Health Sciences, University of Leicester, Leicester, UK.
Objective: Following very preterm birth, some children require ongoing intensive care after the neonatal period and transition directly from neonatal units (NNUs) to paediatric intensive care units (PICUs) around term-corrected age.We aimed to understand, at a national level, characteristics and outcomes of children born very preterm who transitioned directly from NNUs to PICUs.
Design: Retrospective cohort study, using data linkage of National Neonatal Research Database, Paediatric Intensive Care Audit Network and Office for National Statistics datasets.
J Exp Child Psychol
March 2025
Department of Psychological and Brain Sciences, University of Iowa, Iowa City, IA 52245, USA; Stead Family Department of Pediatrics, University of Iowa, Iowa City, IA 52245, USA; DeLTA Center, University of Iowa, Iowa City, IA 52245, USA. Electronic address:
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