AI Article Synopsis
- A novel SARS-CoV-2 virus has led to a global pandemic, prompting a search for treatment methods to prevent its spread.
- Understanding how the virus enters cells can aid in developing entry inhibitors, specifically targeting the ACE2 and heparan sulfate receptors.
- Research shows that cationic peptides G1 and G2 can effectively inhibit virus entry by interacting with these receptors and reducing heparan sulfate levels on cell surfaces.
Article Abstract
A novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic. While the world is striving for a treatment modality against SARS-CoV-2, our understanding about the virus entry mechanisms may help to design entry inhibitors, which may help to limit the virus spreading. Owing to the importance of cellular ACE2 and heparan sulfate in SARS-CoV-2 entry, we aimed to evaluate the efficacy of cationic G1 and G2 peptides in virus entry inhibition. In silico binding affinity studies revealed possible binding sites of G1 and G2 peptides on HS and ACE2, which are required for the spike-HS and spike-ACE2 interactions. Prophylactic treatment of G1 and G2 peptide was also proved to decrease the cell surface HS, an essential virus entry receptor. With these two mechanisms we confirm the possible use of cationic peptides to inhibit the entry of SARS-CoV-2.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308704 | PMC |
| http://dx.doi.org/10.3390/pathogens10070803 | DOI Listing |
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