Effect of Serum Albumin on Porphyrin-Quantum Dot Complex Formation, Characteristics and Spectroscopic Analysis.

Nanomaterials (Basel)

Departamento de Física, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Av. Bandeirantes 3900, Ribeirão Preto 14040-900, Brazil.

Published: June 2021

The effect of bovine serum albumin (BSA) upon interaction between CdTe QD functionalized by 3-Mercaptopropionic Acid (CdTe-3-MPA QD) and two water soluble porphyrins: positively charged -tetra methyl pyridyl porphyrin (TMPyP) and negatively charged -tetrakis(p-sulfonato-phenyl) porphyrin (TPPS), was studied in function of pH using the steady-state and time resolved optical absorption and fluorescence spectroscopies. It was shown that, depending on the charge state of the components, interaction with albumin could either prevent the formation of the QD…PPh complex, form a mixed QD…PPh…BSA complex or not affect PPh complexation with QD at all. The obtained results may be of interest for application in photomedicine.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8308150PMC
http://dx.doi.org/10.3390/nano11071674DOI Listing

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