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3-Benzoylisoxazolines by 1,3-Dipolar Cycloaddition: Chloramine-T-Catalyzed Condensation of α-Nitroketones with Dipolarophiles. | LitMetric

3-Benzoylisoxazolines by 1,3-Dipolar Cycloaddition: Chloramine-T-Catalyzed Condensation of α-Nitroketones with Dipolarophiles.

Molecules

Key Laboratory of Xinjiang Phytomedicine Resource and Utilisation, Ministry of Education, School of Pharmaceutical Sciences, Shihezi University, Shihezi 832002, China.

Published: June 2021

AI Article Synopsis

  • - The study focuses on synthesizing 3-benzoylisoxazolines by reacting alkenes with various α-nitroketones using chloramine-T as the base.
  • - It explores a wide range of α-nitroketones and alkenes, resulting in the formation of different isoxazolines and isoxazoles.
  • - Chloramine-T is highlighted as a cost-effective and user-friendly moderate base for facilitating the 1,3-dipolar cycloaddition reaction.

Article Abstract

In this study, 3-benzoylisoxazolines were synthesized by reacting alkenes with various α-nitroketones using chloramine-T as the base. The scope of α-nitroketones and alkenes is extensive, including different alkenes and alkynes to form various isoxazolines and isoxazoles. The use of chloramine-T, as the low-cost, easily handled, moderate base for 1,3-dipolar cycloaddition is attractive.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8227129PMC
http://dx.doi.org/10.3390/molecules26123491DOI Listing

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