Multi-drug resistant pathogens are a rising danger for the future of mankind. Iodine (I) is a centuries-old microbicide, but leads to skin discoloration, irritation, and uncontrolled iodine release. Plants rich in phytochemicals have a long history in basic health care. Miller (AV) and L. (Sage) are effectively utilized against different ailments. Previously, we investigated the antimicrobial activities of smart triiodides and iodinated AV hybrids. In this work, we combined iodine with Sage extracts and pure AV gel with polyvinylpyrrolidone (PVP) as an encapsulating and stabilizing agent. Fourier transform infrared spectroscopy (FT-IR), Ultraviolet-visible spectroscopy (UV-Vis), Surface-Enhanced Raman Spectroscopy (SERS), microstructural analysis by scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), and X-Ray-Diffraction (XRD) analysis verified the composition of AV-PVP-Sage-I. Antimicrobial properties were investigated by disc diffusion method against 10 reference microbial strains in comparison to gentamicin and nystatin. We impregnated surgical sutures with our biohybrid and tested their inhibitory effects. AV-PVP-Sage-I showed excellent to intermediate antimicrobial activity in discs and sutures. The iodine within the polymeric biomaterial AV-PVP-Sage-I and the synergistic action of the two plant extracts enhanced the microbial inhibition. Our compound has potential for use as an antifungal agent, disinfectant and coating material on sutures to prevent surgical site infections.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8230494 | PMC |
| http://dx.doi.org/10.3390/molecules26123553 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The Carbene Chemistry of -Sulfonyl Hydrazones: The Past, Present, and Future.
Chem Rev
January 2025
Department of Chemistry, Northeast Normal University, Changchun 130024, China.
-Sulfonyl hydrazones have been extensively used as operationally safe carbene precursors in modern organic synthesis due to their ready availability, facile functionalization, and environmental benignity. Over the past two decades, there has been tremendous progress in the carbene chemistry of -sulfonyl hydrazones in the presence of transition metal catalysts, under metal-free conditions, or using photocatalysts under photoirradiation conditions. Many carbene transfer reactions of -sulfonyl hydrazones are unique and cannot be achieved by any alternative methods.
View Article and Find Full Text PDFFacile Synthesis of Mesoporous NiCoO Nanosheets on Carbon Fibers Cloth as Advanced Electrodes for Asymmetric Supercapacitors.
Nanomaterials (Basel)
December 2024
Department of Energy and Power Engineering, North University of China, Taiyuan 038507, China.
The NiCoO Nanosheets@Carbon fibers composites have been successfully synthesized by a facile co-electrodeposition process. The mesoporous NiCoO nanosheets aligned vertically on the surface of carbon fibers and crosslinked with each other, producing loosely porous nanostructures. These hybrid composite electrodes exhibit high specific capacitance in a three-electrode cell.
View Article and Find Full Text PDFSolar Light-Driven Efficient Degradation of Organic Pollutants Mediated by S-Scheme MoS@TiO-Layered Structures.
Nanomaterials (Basel)
December 2024
Key Laboratory for Green Chemical Technology of the Ministry of Education, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China.
This study focuses on achieving high photocatalytic activity using MoS/TiO heterostructures (MOT). To this end, MoS and TiO were synthesized by employing hydrothermal synthesis techniques, and then MoS/TiO heterostructures were synthesized by using 1:1, 1:2, 1:3, and 1:4 ratios of MoS and TiO, respectively. While the structural and electronic changes for the 1:2 and 1:3 ratios were relatively minor, significant modifications in bandgaps and morphology were observed for the 1:1 and 1:4 ratios.
View Article and Find Full Text PDFAsymmetric Synthesis of Azahelicenes via CPA-Catalyzed Kinetic Resolution.
Org Lett
January 2025
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science & Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou 215123, P. R. China.
The azahelicenes are structurally fascinating and practically useful chiral scaffolds, but their synthesis, especially in a catalytically asymmetric manner, is rather challenging. Herein, we report a CPA-catalyzed transfer hydrogenation process, which enables a rapid kinetic resolution of aza[6]helicenes. The established strategy provides facile access to enantioenriched aza[6]helicenes and tetrahydro[6]helicenes from easily available starting materials.
View Article and Find Full Text PDFNickel(II)-hydrazineylpyridine catalyzed regioselective synthesis of α-benzyl substituted β-hydroxy ketones a Fenton free radical reaction.
Org Biomol Chem
January 2025
Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee-247667, Uttarakhand, India.
Ni(II)-hydrazineylpyridine (Ni(II)-PyH)-catalyzed regioselective synthesis of α-benzyl substituted β-hydroxy ketones from α,β-unsaturated ketones and alcohols is reported a Fenton free-radical reaction. This protocol enables facile access to desired products in good to excellent yields in 12 h using toluene solvent at room temperature to 100 °C. The structural analysis of the products was confirmed by H, C-NMR, GC-MS, and HRMS data.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!