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m6A methyltransferase Wilms' tumor 1-associated protein facilitates cell proliferation and cisplatin resistance in NK/T cell lymphoma by regulating dual-specificity phosphatases 6 expression via m6A RNA methylation.
IUBMB Life
January 2021
Department of Hematopathology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Article Synopsis
- Nasal-type natural killer/T-cell lymphoma (NKTCL) is a severe cancer with low survival rates and resistance to chemotherapy, prompting research into the role of m6A RNA modification in its development.
- WTAP, a key enzyme for m6A modifications, is significantly upregulated in NKTCL cells, and reducing its levels impairs cancer cell growth and increases cell death, revealing a potential strategy to overcome chemotherapy resistance.
- The study identifies DUSP6 as a crucial target affected by WTAP-mediated m6A methylation, suggesting that targeting WTAP might improve treatment options for patients with NKTCL.
The Youth Throwing Score: Validating Injury Assessment in Young Baseball Players.
Am J Sports Med
February 2017
Columbia University Medical Center, New York, New York, USA.
Background: Epidemic levels of shoulder and elbow injuries have been reported recently in youth and adolescent baseball players. Despite the concerning frequency of these injuries, no instrument has been validated to assess upper extremity injury in this patient population. Purpose/Hypothesis: The purpose of this study was to validate an upper extremity assessment tool specifically designed for young baseball players.
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