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Photochemical Reactivity of Naphthol-Naphthalimide Conjugates and Their Biological Activity. | LitMetric

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Article Abstract

Quinone methide precursors -, with different alkyl linkers between the naphthol and the naphthalimide chromophore, were synthesized. Their photophysical properties and photochemical reactivity were investigated and connected with biological activity. Upon excitation of the naphthol, Förster resonance energy transfer (FRET) to the naphthalimide takes place and the quantum yields of fluorescence are low (Φ ≈ 10). Due to FRET, photodehydration of naphthols to QMs takes place inefficiently (Φ ≈ 10). However, the formation of QMs can also be initiated upon excitation of naphthalimide, the lower energy chromophore, in a process that involves photoinduced electron transfer (PET) from the naphthol to the naphthalimide. Fluorescence titrations revealed that and form complexes with ct-DNA with moderate association constants ≈ 10-10 M, as well as with bovine serum albumin (BSA) ≈ 10 M (1:1 complex). The irradiation of the complex resulted in the alkylation of the protein, probably via QM. The antiproliferative activity of - against two human cancer cell lines (H460 and MCF 7) was investigated with the cells kept in the dark or irradiated at 350 nm, whereupon cytotoxicity increased, particularly for (>100 times). Although the enhancement of this activity upon UV irradiation has no imminent therapeutic application, the results presented have importance in the rational design of new generations of anticancer phototherapeutics that absorb visible light.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8199699PMC
http://dx.doi.org/10.3390/molecules26113355DOI Listing

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