Bone maturation at the time of diagnosis has been considered as a prognostic factor of congenital hypothyroidism. Using bone area as an index of bone maturation, we have compared the psycho-intellectual outcome of infants with high bone area (group I) at time of diagnosis, with those with low area (group II), in a population of infants with congenital hypothyroidism detected by a neonatal screening program. We found that children from group I had better performances than those from group II whatever the age of the evaluation (1, 2, 5 or 7 years). Nevertheless, the verbal performances of children from group I remained weaker than their non verbal performances and in 7 among 54, the IQ was found to be lower than 90 with a possible relationship with the thyroid insufficiency (bad compliance to treatment) in only one of them.
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