The functional state of T cells is diverse and under dynamic control for adapting to the changes of microenvironment. Reversible protein phosphorylation represents an important post-translational modification that not only involves in the immediate early response of T cells, but also affects their functionality in the long run. Perturbation of global phosphorylation profile and/or phosphorylation of specific signaling nodes result in aberrant T cell activity. Dual specific phosphatases (DUSPs), which target MAPKs and beyond, have increasingly been emerged as a versatile regulator in T cell biology. Herein in this mini review, we sought to summarize and discuss the impact of DUSP proteins on the regulation of effector T cell activity, T cell polarization, regulatory T cell development and T cell senescence/exhaustion. Given the distinctive engagement of each DUSP member under various disease settings such as chronic infection, autoimmune disorders, cancer and age-related diseases, DUSP proteins likely hold the promise to become a druggable target other than the existing therapeutics that are predominantly by manipulating protein kinase activity.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.intimp.2021.107906 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A monoamine oxidase B inhibitor altered gene expression of catalytically active dual-specificity phosphatases in human oral gingival keratinocytes.
Eur Rev Med Pharmacol Sci
December 2024
Department of Oral Biological and Medical Sciences, Faculty of Dentistry, The University of British Columbia, Vancouver, BC, Canada.
Objective: Monoamine oxidase (MAO) inhibitors reduce inflammation in a number of in vitro and in vivo models. This finding led to the development of a novel MAO-B selective inhibitor (RG0216) designed to reduce blood-brain barrier penetration. To elucidate RG0216's regulatory role in inflammation-relevant signaling pathways, we employed a transcriptome analytic approach to identify genes that are differentially regulated by RG0216 and then globally identified which inflammation-relevant biological signaling pathways were altered by this drug.
View Article and Find Full Text PDFThe vertebrate segmentation clock drives segmentation by stabilizing Dusp phosphatases in zebrafish.
Dev Cell
November 2024
Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA; Department of Cell and Developmental Biology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. Electronic address:
Pulsatile activity of the extracellular signal-regulated kinase (ERK) controls several cellular, developmental, and regenerative programs. Sequential segmentation of somites along the vertebrate body axis, a key developmental program, is also controlled by ERK activity oscillation. The oscillatory expression of Her/Hes family transcription factors constitutes the segmentation clock, setting the period of segmentation.
View Article and Find Full Text PDFGenome-wide characterization and comparative expression profiling of genes in yellow catfish () after infection with exogenous .
Front Immunol
November 2024
Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, China.
Article Synopsis
- Dual-specificity phosphatases (DUSPs) are important for regulating immune responses by deactivating specific kinases, but their function in fish like yellow catfish is still not well understood.
- * In this study, researchers identified eight DUSP genes in yellow catfish and analyzed their molecular characteristics, genetic location, and expression during immune responses.
- * Results showed conserved features in these genes and indicated that they play a significant role in the catfish's immune response to bacterial infections, which could be useful for aquaculture practices.
Chronic Inflammatory Pain Alters Expression of Limbic MAPK Phosphatases.
Chronic Pain Manag
February 2024
Department of Physiology and Pharmacology, Des Moines University, Des Moines, IA 50312, USA.
Article Synopsis
- Chronic pain and depression are linked, but the brain mechanisms behind this link are not well understood.
- This study found that chronic pain increases the expression of a gene called MKP-1 in areas of the brain related to emotions in both male and female rats, although patterns of expression varied between sexes.
- Low-dose ketamine treatment was able to block the pain-induced increase in MKP-1, suggesting that targeting this gene may help address mood disorders related to chronic pain.
PEGylated Titanium Dioxide Nanoparticle-bound Doxorubicin and Paclitaxel Drugs Affect Prostate Cancer Cells and Alter the Expression of DUSP Family Genes.
Anticancer Agents Med Chem
October 2024
Department of Medical Biochemistry, Faculty of Medicine, Sivas Cumhuriyet University, Sivas, 58140, Türkiye.
Background: PC is among the cancer types with high incidence and mortality. New and effective strategies are being sought for the treatment of deadly cancers, such as PC. In this context, the use of nanocarrier systems containing titanium dioxide can improve treatment outcomes and increase the effectiveness of anticancer drugs.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!