Introduction: Family history is a risk factor for colorectal cancer (CRC), however whether family history also contributes to non-syndromic early-onset CRC is unknown.
Methods: We estimated risk to first-, second-, and third-degree relatives of early-onset CRC cases in the Utah Pedigree Database.
Results: We observed elevated risks beyond RR = 2.0 for early-onset CRC among first- and second-degree relatives of early-onset CRC cases, with RRs of 6.0 and 3.1, respectively.
Discussion: Relatives of early-onset CRC cases are at higher risk of both early-onset CRC and CRC at any age, and the location is not necessarily similar to the affected relative.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8316419 | PMC |
| http://dx.doi.org/10.1016/j.canep.2021.101973 | DOI Listing |
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