Catechol-Bearing Polyketide Derivatives from .

Sparticols A () and B (), two catechol-bearing naphthalenedioxy derivatives, were isolated from the submerged culture of the Spanish broom inhabiting Dothideomycetes fungus, The structures of and were established by NMR spectroscopic analysis and high-resolution mass spectrometry. The 8 absolute configuration of their β-hydroxy functionalities was determined by ECD-TDDFT. Both compounds exhibited inhibitory activity against with an MIC value of 66.6 μg/mL. Polyketides and/or may be associated with pathways cascading to -spirodioxynapthalene derivatives.