AI Article Synopsis
- - Hodgkin's lymphoma is a type of cancer that affects B lymphocytes and is characterized by the presence of unique binucleate cells called Reed-Sternberg cells.
- - It occurs mainly in two age groups: teenagers and young adults (around 20–30 years), and again in older adults (55+ years).
- - Treatment decisions depend on the specific subtype of Hodgkin's lymphoma, its stage, and various prognostic factors, influencing the management approach.
Article Abstract
Hodgkin's lymphoma is due to the clonal transformation of cells originating from B lymphocytes, generating the pathognomonic binucleate Reed-Sternberg cells. Hodgkin's lymphoma is a B cell disease with a bimodal distribution, with higher incidence in adolescence and the third decade of life, showing a second peak in people over 55 years of age. Classic Hodgkin lymphoma cells routinely undergo gene expression reprogramming, as they lose the expression of most of the typical B-cell genes and acquire the expression of multiple genes that are typical of other types of cells in the immune system. The treatment algorithm will depend on whether it is classic or predominantly lymphocytic HL, if it is early stage with unfavorable prognostic markers or not, the initial management regimen, and whether there is bulky disease, among the most relevant variables.
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| http://dx.doi.org/10.24875/GMM.M21000500 | DOI Listing |
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