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| http://dx.doi.org/10.1172/JCI152477 | DOI Listing |
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Case report: A novel third-generation anti-CD19/CD22 CAR T-cells combined with auto-HSCT for relapsed Burkitt lymphoma.
Front Immunol
December 2024
The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
This study explores a novel therapeutic strategy for relapsed/refractory (R/R) Burkitt lymphoma (BL) by integrating autologous hematopoietic stem cell transplantation (ASCT) with tandem anti-CD19/CD22 chimeric antigen receptor (CAR) T cell therapy. A 20-year-old Asian male with refractory BL, whose lymphoma had not responded to multiple chemoimmunotherapy regimens, received myeloablative ASCT followed three days later by infusion of a novel third-generation CAR T cells engineered with CD28 and CD3ζ signaling domains, along with a TLR2 costimulatory domain. This resulted in sustained complete remission at the 306-day follow-up, without experiencing any severe complications.
View Article and Find Full Text PDFProteomics for forensic identification of saliva and vomit in a case of alleged rape.
Anal Bioanal Chem
December 2024
Institute of Food Sciences, National Research Council (CNR), Via Roma 64, 83100, Avellino, Italy.
In crime investigations, the unambiguous identification of biological traces can be decisive for framing the events. In this study, we applied proteomics to analyze scant amounts of biological residues in the context of an alleged rape case, focusing on the detection of traces of vomit. We used high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) and two distinct proteomic workflows to identify proteins and possible proteolytic peptides in biological residues from clothing, bedding, and car upholstery from the alleged crime scene.
View Article and Find Full Text PDFARI0003: Co-transduced CD19/BCMA dual-targeting CAR-T cells for the treatment of non-Hodgkin lymphoma.
Mol Ther
November 2024
Fundació de Recerca Clínic Barcelona-Institut d'Investigacions Biomèdiques August Pi Sunyer (FRCB-IDIBAPS), 08036 Barcelona, Spain. Electronic address:
Article Synopsis
- * Researchers explored dual-targeting strategies by combining anti-CD19 and anti-BCMA CAR-T cells to enhance effectiveness, optimizing various co-transduction methods and demonstrating improved targeting of tumor cells with the new approach, ARI0003.
- * A first-in-human trial (CARTD-BG-01, NCT06097455) has been launched to assess the safety and efficacy of ARI0003, which was manufactured under strict conditions to lower the risk of genotoxicity.
The human plasma lipidome response to exertional heat tolerance testing.
Lipids Health Dis
November 2024
Biological Sciences Division, Richland, WA, 99352, USA.
Background: The year of 2023 displayed the highest average global temperatures since it has been recorded-the duration and severity of extreme heat are projected to increase. Rising global temperatures represent a major public health threat, especially to occupations exposed to hot environments, such as construction and agricultural workers, and first responders. Despite efforts of the scientific community, there is still a need to characterize the pathophysiological processes leading to heat related illness and develop biomarkers that can predict its onset.
View Article and Find Full Text PDFProteomic study of medicinal mushroom extracts reveals antitumor mechanisms in an advanced colon cancer animal model via ribosomal biogenesis, translation, and metabolic pathways.
Front Pharmacol
October 2024
Faculty of Health Studies, University of Rijeka, Rijeka, Croatia.
Introduction: Colorectal cancer ranks as the third most common cancer in both men and women, with approximately 35% of cases being stage IV metastatic at diagnosis. Even with treatment advancements, the survival rates for these patients remain suboptimal. There is a significant focus on developing multi-targeted therapies due to the common issue of drug resistance in standard and targeted cancer treatments.
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