In this issue, Aboulouard et al. (2021) use spatially resolved shot-gun proteomics to characterize the sentinel lymph nodes (SLNs) of endometrial cancer patients at different pathological grades. They identify biomarkers that predict prognosis as well as tumor grade.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233646 | PMC |
http://dx.doi.org/10.1016/j.xcrm.2021.100283 | DOI Listing |
J Ovarian Res
January 2025
Department of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, #128 Shenyang Road, Shanghai, 200090, People's Republic of China.
Background: Ovarian cancers (OC) and cervical cancers (CC) have poor survival rates. Tumor-infiltrating lymphocytes (TILs) play a pivotal role in prognosis, but shared immune mechanisms remain elusive.
Methods: We integrated single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics (ST) to explore immune regulation in OC and CC, focusing on the PI3K/AKT pathway and FLT3 as key modulators.
Sensors (Basel)
January 2025
Faculty of Architecture and Civil Engineering, Karlsruhe University of Applied Sciences, 76133 Karlsruhe, Germany.
Engineers, geomorphologists, and ecologists acknowledge the need for temporally and spatially resolved measurements of sediment clogging (also known as colmation) in permeable gravel-bed rivers due to its adverse impacts on water and habitat quality. In this paper, we present a novel method for non-destructive, real-time measurements of pore-scale sediment deposition and monitoring of clogging by using wire-mesh sensors (WMSs) embedded in spheres, forming a smart gravel bed (GravelSens). The measuring principle is based on one-by-one voltage excitation of transmitter electrodes, followed by simultaneous measurements of the resulting current by receiver electrodes at each crossing measuring pores.
View Article and Find Full Text PDFJ Clin Med
January 2025
Department of Trauma Surgery, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.
: Tactile gnosis derives from the interplay between the hand's tactile input and the memory systems of the brain. It is the prerequisite for complex hand functions. Impaired sensation leads to profound disability.
View Article and Find Full Text PDFMaterials (Basel)
January 2025
State Key Laboratory of Radio Frequency Heterogeneous Integration, International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology, Institute for Advanced Study in Nuclear Energy & Safety, Interdisciplinary Center of High Magnetic Field Physics of Shenzhen University, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China.
With the rapid advancement of information technology, the data demands in transmission rates, processing speed, and storage capacity have been increasing significantly. However, silicon electro-optic modulators, characterized by their weak electro-optic effect, struggle to balance modulation efficiency and bandwidth. To overcome this limitation, we propose an electro-optic modulator based on an all-fiber micro-ring resonator and a p-Si/n-ITO heterojunction, achieving high modulation efficiency and large bandwidth.
View Article and Find Full Text PDFBiomedicines
January 2025
Department of Immunotechnology, Faculty of Engineering (LTH), Lund University, 223 63 Lund, Sweden.
Mycosis fungoides (MF) is a rare malignancy, with an indolent course in the early stages of the disease. However, due to major molecular and clinical heterogeneity, patients at an advanced stage of the disease have variable responses to treatment and considerably reduced life expectancy. Today, there is a lack of specific markers for the progression from early to advanced stages of the disease.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!