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Exploring the Link Between Renal Function Fluctuations Within the Physiological Range and Serum/CSF Levels of NfL, GFAP, tTAU, and UCHL1.
Int J Mol Sci
January 2025
Department of Neurology, University Hospital Frankfurt, Goethe University, 60590 Frankfurt am Main, Germany.
Impaired renal function can influence biomarker levels through mechanisms involving blood-brain barrier integrity and clearance pathways; however, the impact of variations within normal renal function remains unclear. The main aim of this study was to determine whether adjustment for the specific level of renal function is necessary when renal function remains within physiological levels. We studied n = 183 patients (NID n = 122; other neurological diseases n = 39; somatoform controls n = 22) who underwent lumbar puncture at University Hospital Frankfurt.
View Article and Find Full Text PDFBackground: The World Health Organization (WHO) recommended cryptococcal antigen (CrAg) screening for people presenting with advanced HIV disease (AHD) and for those with positive CrAg without evidence of meningitis to initiate preemptive antifungal medication. Data on the implementation of WHO recommendations regarding CrAg screening is limited. We estimated pooled prevalence of CrAg screening uptake, cryptococcal antigenemia, lumbar puncture, cryptococcal meningitis and initiation of preemptive antifungal medication from available eligible published studies conducted in Africa.
View Article and Find Full Text PDFPerformance of clinical decision aids (CDA) for the care of young febrile infants: a multicentre prospective cohort study conducted in the UK and Ireland.
EClinicalMedicine
December 2024
Wellcome Wolfson Institute of Experimental Medicine, Queen's University Belfast, Belfast, UK.
Background: Between 1% and 4% of febrile infants, aged from birth to 90 days of age, presenting to hospital will be diagnosed with an invasive bacterial infection (IBI). Traditional teaching has advocated a treat all approach but more recently a number of clinical decision aids (CDA) have been developed to classify febrile infants into lower and higher risk cohorts, with lower risk infants suitable for management without immediate parenteral antibiotics and lumbar puncture. The aim of this study was to apply these CDA to a UK and Irish cohort.
View Article and Find Full Text PDFSpinal Anatomy Ultrasound in Young Infants With Implications for Lumbar Puncture.
Pediatr Emerg Care
December 2024
Department of Pediatrics, Division of Pediatric Emergency Medicine, Monroe Carell Jr. Children's Hospital at Vanderbilt and Vanderbilt University Medical Center, Nashville, TN.
Background: Lumbar puncture (LP) in young infants may challenge clinicians due to the infrequency of the procedure and anatomic variability. The use of ultrasound (US) to characterize young infant spinal anatomy prior to performing an LP may help determine the most favorable site for intervention.
Objectives: 1) Evaluate potential sites for LP in young infants with US at L2/L3 through L5/S1 to determine differences in needle insertion depth (NID), spinal canal width (SCW), and subarachnoid fluid width (SAW).
CORRELATION OF SONOGRAPHIC OPTIC NERVE SHEATH DIAMETER WITH OPENING PRESSURE ON LUMBAR PUNCTURE IN PATIENTS OF IDIOPATHIC INTRACRANIAL HYPERTENSION.
J Ayub Med Coll Abbottabad
December 2024
MTI-Hayatabad Medical Complex, Peshawar-Pakistan.
Article Synopsis
- A study evaluated the correlation between the optic nerve sheath diameter (ONSD) measured via ultrasound and the opening pressure (OP) of cerebrospinal fluid (CSF) in patients diagnosed with idiopathic intracranial hypertension (IIH), highlighting ONSD as a non-invasive alternative to traditional lumbar puncture.
- Conducted from June 2021 to May 2023, the study included 50 participants (25 with IIH and 25 controls), comparing their ONSD and OP measurements to establish a relationship.
- Results showed that a mean ONSD of 5.60 mm can effectively indicate raised intracranial pressure with high sensitivity and specificity, suggesting its use as a reliable, non-invasive assessment tool
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