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Self-Wrinkling-Induced Mechanically Adaptive Patterned Surface of Photocuring Coating for Abrasion Resistance.
Adv Mater
December 2024
School of Chemistry & Chemical Engineering, Frontiers Science Center for Transformative Molecules, State Key Laboratory for Metal Matrix Composite Materials, Shanghai Jiao Tong University, Shanghai, 200240, China.
Providing mechanically adaptive performance to surfaces is significant in preserving materials from damage in variable environments, however, it has rarely been studied. Inspired by the mechanically adaptive behaviors of the surface microstructure on the carapace of desert scorpions and bark of desert tamarisks, a self-wrinkled mechanically adaptive patterned surface (SWMAPS) using one-step UV-curing and self-wrinkling technique is reported. Because of the fluorinated polyurethane photo-initiator formed by self-assembly at the top surface, UV-induced photo-crosslinking can spontaneously generate a gradient-crosslinked structure and wrinkled patterns with different morphology.
View Article and Find Full Text PDFLupus-prone NZM2328 mice exhibit enhanced UV-induced myeloid cell recruitment and activation in a type I interferon dependent manner.
J Autoimmun
December 2024
Div. of Rheumatology, Dept. of Internal Medicine, University of Michigan, Ann Arbor, MI, USA; Department of Dermatology, University of Michigan, Ann Arbor, MI, USA. Electronic address:
Article Synopsis
- Exposure to ultraviolet (UV) light is a known trigger for inflammation in systemic lupus erythematosus (SLE), but the specific cells involved in this response and how UV exposure interacts with interferons are not fully understood.
- This study utilized a murine model of lupus, comparing responses in NZM2328 mice and iNZM mice with a type I interferon receptor knockout, as well as wild-type BALB/c mice, to investigate the effects of different UV treatments.
- Findings showed that myeloid cells, particularly neutrophils and monocyte-derived dendritic cells, play a key role in the inflammatory response to UV exposure in lupus-prone mice, emphasizing the potential for targeting type I interferons and
Epidermal ZBP1 stabilizes mitochondrial Z-DNA to drive UV-induced IFN signaling in autoimmune photosensitivity.
bioRxiv
January 2024
Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor.
Photosensitivity is observed in numerous autoimmune diseases and drives poor quality of life and disease flares. Elevated epidermal type I interferon (IFN) production primes for photosensitivity and enhanced inflammation, but the substrates that sustain and amplify this cycle remain undefined. Here, we show that IFN-induced Z-DNA binding protein 1 (ZBP1) stabilizes ultraviolet (UV)B-induced cytosolic Z-DNA derived from oxidized mitochondrial DNA.
View Article and Find Full Text PDFInterpenetrating Polymer Network HA/Alg-RGD Hydrogel: An Equilibrium of Macroscopic Stability and Microscopic Adaptability for 3D Cell Growth and Vascularization.
Biomacromolecules
December 2023
School of Nano-Tech and Nano-Bionics, University of Science and Technology of China, Hefei, 230026, China.
Two-dimensional (2D) cell culture methods dominate the current research. However, the inherent responsiveness of cells to their native three-dimensional (3D) microenvironment necessitates a paradigm shift toward the development of advanced hydrogels that faithfully mimic the intricacies of the extracellular matrix (ECM) and enable continuous cell-ECM interactions. To address the constraints of traditional static hydrogel networks that impede effective cell-matrix and cell-cell interactions, and to tackle the inherent stability issues associated with dynamically cross-linked hydrogels, which have become a pressing concern.
View Article and Find Full Text PDFDetection of Primary DNA Lesions by Transient Changes in Mating Behavior in Yeast Using the Alpha-Test.
Int J Mol Sci
July 2023
Vavilov Institute of General Genetics, St. Petersburg Branch, Russian Academy of Sciences, 199034 St. Petersburg, Russia.
Spontaneous or induced DNA lesions can result in stable gene mutations and chromosomal aberrations due to their inaccurate repair, ultimately resulting in phenotype changes. Some DNA lesions per se may interfere with transcription, leading to temporary phenocopies of mutations. The direct impact of primary DNA lesions on phenotype before their removal by repair is not well understood.
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