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Eco-friendly synthesis of betanin-conjugated zinc oxide nanoparticles: antimicrobial efficacy and apoptotic pathway activation in oral cancer cells.
Mol Biol Rep
November 2024
Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, P.O. Box. 2454, 11451, Saudi Arabia.
Background: Phytochemical-based synthesis of nanoparticles (NPs) is an eco-friendly approach with various biomedical applications. Betanin, a natural pigment in beetroot, has antioxidant, anti-inflammatory, and antimicrobial properties. When conjugated with zinc oxide nanoparticles (ZnO NPs), these properties are enhanced.
View Article and Find Full Text PDFTruffle protein and its derived peptides exhibit sleep-promoting effects via regulation of lysosomal autophagy, neurological activity, tyrosine metabolism, and fatty acid elongation.
Int J Biol Macromol
November 2024
College of Food Science and Technology, Yunnan Agricultural University, Kunming, Yunnan 650201, China; Agro-products Processing Research Institute, Yunnan Academy of Agricultural Sciences, Kunming, Yunnan 650221, China. Electronic address:
Article Synopsis
- This study focuses on the sleep-promoting effects of black truffle protein, specifically truffle albumin (TA) and its hydrolysate (TAH), in insomnia-prone fruit flies (Drosophila).
- The research discovered that both TA and TAH significantly increased sleep duration and quality, and identified two peptides, YLDLAPL and YLRPEGDW, that enhance sleep.
- Additionally, transcriptomics analysis revealed potential mechanisms for these sleep-enhancing effects, including improved neuronal function, regulation of neurotransmitter production, and protection against oxidative stress in nerve cells.
Isolation and Characterization of Antioxidant Peptides from Dairy Cow () Placenta and Their Antioxidant Activities.
Antioxidants (Basel)
July 2024
The Key Laboratory of Animal Disease and Human Health of Sichuan Province, The Medical Research Center for Cow Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China.
Our preliminary study identified dairy cow placenta extract (CPE) as a mixture of peptides with potent antioxidant activity both in vivo and in vitro. However, the specific antioxidant peptides (AOPs) responsible for this activity were not yet identified. In the current study, we employed virtual screening and chromatography techniques to isolate two peptides, ANNGKQWAEVF (CP1) and QPGLPGPAG (CP2), from CPE.
View Article and Find Full Text PDFOptimization of the Search for Neuroprotectors among Bioflavonoids.
Pharmaceuticals (Basel)
July 2024
Department of Microbiology, Virology and Immunology, I. Horbachevsky Ternopil State Medical University, 46001 Ternopil, Ukraine.
For the first time, to optimize the creation of new neuroprotective agents based on bioflavonoids, we applied information technologies; these include docking analysis to calculate the binding of candidate molecules to the pharmacological target protein transthyretin as well as a program of virtual screening of NO scavengers. As a result of this approach, the substance catechin was isolated from candidate molecules-quercetin, catechin, Epicatechin gallate, Epicatechin, Procyanidin B1, Procyanidin B2, Procyanidin B3, and Catechin-3-gallate-according to docking analysis. As a result of virtual screening, catechin was identified as a potential NO scavenger (55.
View Article and Find Full Text PDFConstituents from Dendrobium aphyllum: Bibenzyls, furfurals, phenanthrenes, and phenylpropanoids and their antioxidant and anti-inflammatory potentials.
Fitoterapia
September 2024
State Key Laboratory of Chinese Medicine Modernization, State Key Laboratory of Component-based Chinese Medicine, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai District, Tianjin 301617, People's Republic of China; Tianjin Key Laboratory of Therapeutic Substance of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai District, Tianjin 301617, People's Republic of China. Electronic address:
Chemical investigation on the aqueous extract of Dendrobium aphyllum led to the isolation of thirty-one constituents with structures identified by analysis of the extensive spectroscopic data (1D/2D NMR, MS, UV, and ECD), including previously undescribed two bibenzyls, one furfural, and one phenolic acid, namely trigonopol D (1), trigonopol C (2), dendrofunan A (10), and 6-(4-hydroxy-3-methoxyphenyl)-3,6-dioxohexyl acetate (30), respectively, as well as twenty-seven known ones. Among them, there were one new natural product (11), seven compounds (6-7, 9, 12, 20, 28, 31) described from the genus Dendrobium for the first time, and fifteen compounds (8, 13-17, 19, 21-27, 29) isolated from D. aphyllum for the first time.
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