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Therapeutic potential of ketone bodies on exercise intolerance in heart failure: looking beyond the heart.
Cardiovasc Res
January 2025
Cardiovascular Research Centre, University of Alberta, Edmonton, Alberta, Canada.
Recent evidence suggests that ketone bodies have therapeutic potential in many cardiovascular diseases including heart failure (HF). Accordingly, this has led to multiple clinical trials that use ketone esters to treat HF patients, which we term ketone therapy. Ketone esters, specifically ketone monoesters, are synthetic compounds which, when consumed, are de-esterified into two β-hydroxybutyrate (βOHB) molecules and increase the circulating βOHB concentration.
View Article and Find Full Text PDFDevelopment and initial validation of the group exercise motivation scale and associated factors in an Asian population.
J Sports Sci
January 2025
School of Nursing, University of Pennsylvania, Philadelphia, PA, USA.
Backgrounds: Physical activity is crucial in health promotion. Exercise in groups can strengthen the benefits of exercise itself. However, the scale measuring the motivation for group exercise is scare.
View Article and Find Full Text PDFAssociation between physical activity and cognitive function in post-menopausal women with high parity: the chain-mediating effects of nutritional status and depression.
BMC Womens Health
January 2025
Department of Laboratory Medicine, Huashan Hospital, Fudan University, Shanghai, China.
Background: It has been reported that the cognitive responses to physical activity (PA) in postmenopausal women vary by parity status, and women with higher parity show a significant association between PA and cognitive function. However, the potential pathways mediating the relationship between PA and cognitive function in women with higher parity remain unclear. The objective of this study was to examine this association in Chinese cohort and further investigate the mediating pathways.
View Article and Find Full Text PDFOptimal dose and type of exercise improve walking velocity in adults with Parkinson's disease: a systematic review and Bayesian network meta-analysis.
Sci Rep
January 2025
School of Gerontology and Long-Term Care, Taipei Medical University, Taipei City 110, Taiwan (R.O.C.), Taipei, Taiwan.
To examine the dose-response relationship between specific types of exercise for improving walking velocity in Parkinson's disease (PD). This systematic review and network meta-analysis included searches of PubMed, Medline, Embase, PsycINFO, Cochrane Library, and Web of Science were searched from inception until February 18th, 2024. Data analysis was performed using R software with the MBNMA and RJAGS packages.
View Article and Find Full Text PDFUnderstanding the role of metabolic syndrome in prostate cancer risk: A UK Biobank prospective cohort study.
Sci Rep
January 2025
Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK.
Predictive value of metabolic syndrome for prostate cancer risk is not clear. We aimed to assess the association between metabolic syndrome and its components with prostate cancer incidence. The primary outcome was prostate cancer incidence, i.
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