AI Article Synopsis
- Chirality significantly impacts how molecules behave in biological systems, as even small changes can lead to major differences in functionality.
- The study introduces a new color-changing indicator that can visibly detect variations in the chirality of chiral amines, with changes observable due to as little as 2% differences in enantiomeric excess (ee).
- This color indicator utilizes a special polymer that responds to solvent conditions, enabling quick, on-site chirality detection and quantification of ee values, which is especially useful for analyzing drugs and other nonracemic amines.
Article Abstract
Chirality plays a key role in the physiological system, because molecular functionalities may drastically alter due to a change in chirality. We report herein a unique color indicator with a static helicity memory, which exhibits visible color changes in response to the chirality of chiral amines. A difference of less than 2% in the enantiomeric excess (ee) values causes a change in the absorption that is visible to the naked eyes. This was further quantified by digital photography by converting to RGB values. This system relies on the change in the tunable helical pitch of the π-conjugated polymer backbone in specific solvents and allows rapid on-site monitoring of chirality of nonracemic amines, including drugs, and the simultaneous quantitative determination of their ee values.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8245042 | PMC |
| http://dx.doi.org/10.1126/sciadv.abg5381 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!