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Exposure to cisplatin in the operating room during hyperthermic intrathoracic chemotherapy. | LitMetric

Exposure to cisplatin in the operating room during hyperthermic intrathoracic chemotherapy.

Int Arch Occup Environ Health

Germany and Comprehensive Pneumology Center Munich, University Hospital, LMU Munich, Institute and Clinic for Occupational, Social and Environmental Medicine, Munich, Germany.

Published: March 2022

AI Article Synopsis

  • Hyperthermic intrathoracic chemotherapy (HITOC) is a treatment for malignant pleural tumors that involves using a cisplatin solution in the thoracic cavity after surgery to enhance tumor control.
  • A study assessed the presence of cisplatin on surfaces and medical staff's gloves during ten HITOC procedures to evaluate potential contamination and occupational safety risks.
  • The results showed relatively high cisplatin levels on surgeons' and perfusionists' gloves but low levels on surrounding surfaces, indicating that proper protective measures can lead to a low risk of exposure during HITOC.

Article Abstract

Purpose: Hyperthermic intrathoracic chemotherapy (HITOC) is an additive, intraoperative treatment for selected malignant pleural tumors. To improve local tumor control, the thoracic cavity is perfused with a cisplatin-containing solution after surgical cytoreduction. Since cisplatin is probably carcinogenic to humans, potential contamination of surfaces and pathways of exposure should be systematically investigated to enable risk assessments for medical staff and thus derive specific recommendations for occupational safety.

Methods: Wipe sampling was performed at pre-selected locations during and after ten HITOC procedures, including on the surgeon's gloves, for the quantitation of surface contaminations with cisplatin. After extraction of the samples with hydrochloric acid, platinum was determined as a marker for cisplatin by voltammetry.

Results: High median concentrations of cytostatic drugs were detected on the surgeons' (1.73 pg Cis-Pt/cm, IQR: 9.36 pg Cis-Pt/cm) and perfusionists' (0.69 pg Cis-Pt/cm, IQR: 1.73 pg Cis-Pt/cm) gloves. The display of the perfusion device showed partially elevated levels of cisplatin up to 4.92 pg Cis-Pt/cm and thus could represent an origin of cross-contamination. In contrast, cisplatin levels on the floor surfaces in the area of the surgeon and the perfusion device or in the endobronchial tube were relatively low.

Conclusion: With a correct use of personal protective equipment and careful handling, intraoperative HITOC appears to be safe to perform with a low risk of occupational exposure to cisplatin.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8795016PMC
http://dx.doi.org/10.1007/s00420-021-01738-3DOI Listing

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