Pulmonary talcosis related to cocaine inhalation.

J Bras Pneumol

. Universidade Federal do Rio de Janeiro. Rio de Janeiro (RJ) Brasil.

Published: June 2021

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8332722PMC
http://dx.doi.org/10.36416/1806-3756/e20210146DOI Listing

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Inhaled particles that are poorly soluble or insoluble and of low toxicity ("poorly soluble low toxicity" or "PSLT" particles), can accumulate in the lung and at lung overload levels induce lung cancers in rats. The question of whether PSLT particles increase lung cancer risk in humans is complicated by large differences between rats and humans and the relatively large particle doses administered in animal studies even when compared with heavy human occupational exposures. We review the findings of epidemiological studies on occupational exposure to each of three different PSLT particles (carbon black, talc and taconite).

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Pulmonary talcosis is a rare pneumoconiosis that is difficult to diagnose and may progress to debilitating lung disease. Four types of talcosis are described in literature: talc-silicosis and talc-asbestosis secondary to inhalation in industry workers and talc-emboli in intravenous drug users that self-inject talc-containing oral tablets. Although found in common household products, talc is overlooked as a cause of pneumoconiosis.

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RiceSorb as Talcum Substitute for Loose Face Powders: Formulation and Characterization.

J Cosmet Sci

December 2020

Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Songkhla 90112, Thailand (A.S., P.C., D.M., N.K., S.S.), Drug Delivery System Excellence Center, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand (D.M., N.K., S.S.).

Excessive and daily inhalation of talcum, a main ingredient of face powders, causes pulmonary talcosis, which has led to the replacement of talcum with safer natural ingredients. RiceSorb, or starch from Japanese rice, was used as an alternative owing to its nontoxic and excellent oil absorption capacity. The objectives of the present work were to formulate loose face powders from RiceSorb and to investigate the physicochemical properties of the prepared formulations.

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