AI Article Synopsis
- A study examined the outcomes of pregnant women with cerebral venous sinus thrombosis (CVST) who were treated with anticoagulants from 2009 to 2018, comparing them to non-pregnant women with the same condition.
- Results showed that while pregnancy-related patients had more severe conditions before treatment, their 12-month recovery rates were similar to those of non-pregnant patients.
- Those with poor outcomes in the pregnancy-related group tended to have fewer cases of sigmoid sinus thrombosis, higher instances of coma, and higher modified Rankin scales (mRS) before treatment.
Article Abstract
Background: To describe the outcome of the patients with cerebral venous sinus thrombosis (CVST) during pregnancy and postpartum treated with anticoagulant therapy.
Methods: This is a retrospective cohort study and patients with CVST were collected from October 2009 to March 2018. Patients were divided into pregnancy-related (occurred during pregnancy and postpartum) group and non-pregnancy-related. Recovery rate at 12 months after anticoagulant therapy, adverse events, characteristics of patients with poor outcomes were statistically analyzed.
Results: Fifty-eight pregnancy-related CVST patients (17 pregnancy and 41 postpartum) as study group and 76 non-pregnancy-related CVST women as control group were enrolled. Study group was statistically different to control group in several baseline variables. More pregnancy-related patients had modified rankin scale (mRS) = 5 (15.5% vs 11.8%, P = 8.1×10-3) before anticoagulant therapy. At 12 months heparinization, difference in recovery rate was not statistically significant (80% vs 87.5%, P = .29) between 2 groups. No differences were found of adverse events between 2 groups. Patients with poor outcomes had less sigmoid sinus thrombosis (16.7% vs 61.5%, P = .14), more coma (41.2% vs 17.2%, P = 5.2×10-7), more mRS = 4 (33.3% vs 19.2%, P = 1.63 × 10-4), more mRS = 5 (66.7% vs 9.6%, P = 1.63 × 10-4) before treatment.
Conclusion: Pregnancy-related CVST patients had severer condition before treatment, but can achieve comparable recovery rate at 12 months after anticoagulant therapy with non-pregnancy-related women. Pregnancy-related patients with poor prognosis had less sinus sigmoid occlusion, more coma, high mRS at admission.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8257884 | PMC |
| http://dx.doi.org/10.1097/MD.0000000000026360 | DOI Listing |
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