Johne's disease (JD) is a chronic granulomatous enteritis caused by subsp. (MAP). While it is generally accepted that MAP employs immune subversion mechanisms, aspects of the host-pathogen relationship are not fully understood. We sampled 3 ileal tissue sections from 17 naturally infected cattle ( = 51 sections) to analyze differences in cell types, apoptosis, and phagocytic cells. Diffuse multibacillary (DM) was the most common lesion type ( = 17) followed by diffuse intermediate (DI; = 15). DM lesions had significantly greater proportion of Treg cells (CD3 FoxP3 relative to all CD3 T cells as compared to DI forms ( < .05). CD68 individual cell size was significantly smaller in DM than in diffuse lymphocytic (DL) forms ( < .05). Area of caspase-3 positivity (apoptosis) was greater in DM lesions than DL ( < .05) and DI ( < .0001), and was linked to higher numbers of MAP within the macrophage.
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| http://dx.doi.org/10.1177/03009858211025790 | DOI Listing |
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