NOTCH-ing up nucleotide metabolism in T-cell acute lymphoblastic leukemia.

Commun Biol

Department of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

Published: June 2021

In a recent issue of Science Advances, Srivastava et al. report a novel nucleotide biosynthesis regulatory role for UBR7 in NOTCH1-driven T-ALL. Here we will discuss their key findings and the implications for using cancer metabolism to understand the development and progression of T-ALL.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8241981PMC
http://dx.doi.org/10.1038/s42003-021-02330-8DOI Listing

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