Two new hydroquinones bearing a 1,3-enyne moiety, pestalotioquinols G and H, together with four known compounds, including pestalotioquinol A, phomonitroester, ()-4,6,8-trihydroxy-3,4-dihydronaphthalen-1(2)-one, and scylatone were isolated from the marine fungus (BCC 35283). The structures of these compounds were elucidated by analysis of 2D-NMR and HR-MS data. The known pestalotioquinol A displayed antimalarial activity against K1 with an IC value of 19.0 μM, while pestalotioquinol G displayed weak cytotoxic activity against Vero cell lines with an IC value of 47.9 μM.
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| http://dx.doi.org/10.1080/14786419.2021.1946536 | DOI Listing |
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Two new farnesyl hydroquinones from (BCC 35283), the fungus associated with algae.
Nat Prod Res
January 2023
National Biobank of Thailand (NBT), National Science and Technology Development Agency (NSTDA), Thailand Science Park, Pathum Thani, Thailand.
Two new hydroquinones bearing a 1,3-enyne moiety, pestalotioquinols G and H, together with four known compounds, including pestalotioquinol A, phomonitroester, ()-4,6,8-trihydroxy-3,4-dihydronaphthalen-1(2)-one, and scylatone were isolated from the marine fungus (BCC 35283). The structures of these compounds were elucidated by analysis of 2D-NMR and HR-MS data. The known pestalotioquinol A displayed antimalarial activity against K1 with an IC value of 19.
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