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Higher serotonin levels among patients with rheumatoid arthritis, psoriatic arthritis, and axial spondyloarthritis compared to healthy controls assessed by liquid chromatography-tandem mass spectrometry (LC-MS).
Rheumatol Int
January 2025
Department of Rheumatology and Immunology, Jagiellonian University Medical College, Jakubowskiego 2, Kraków, 30-688, Poland.
Growing evidence suggests that serotonin is an important mediator in the cross-talk between immune and bone cells, playing a role in the pathogenesis of various types of inflammatory arthritis (IA). However, the relationship between circulating serotonin and different outcomes in three most prevalent IA - rheumatoid arthritis (RA), psoriatic arthritis (PsA), and axial spondyloarthritis (axSpA), remains limited and requires further investigation. This study was performed to evaluate variations in serotonin serum levels among RA, PsA, and axSpA and to explore the utility of this biochemical marker in the assessment of disease activity and health status measurements provided by the Multi-Dimensional Health Assessment Questionnaire (MDHAQ).
View Article and Find Full Text PDFMetabolic Characterization of Cerebrospinal Fluid for Patients With Autoimmune Encephalitis: A Preliminary Study.
CNS Neurosci Ther
January 2025
Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Article Synopsis
- This research investigates the potential biomarkers and metabolic changes in cerebrospinal fluid (CSF) of patients with autoimmune encephalitis (AE) compared to healthy controls.
- A total of 21 potential biomarkers were identified, with elevated levels of pyruvic and oxoglutaric acids, pointing to a dysregulated TCA cycle in AE patients.
- Additionally, the study highlights differences in unsaturated fatty acid metabolism, indicating that these metabolic pathways may play a significant role in understanding the pathology of AE.
Precise Light-Driven Polarity of Stationary Phase for Regulating Gradient Separation of Liquid Chromatography.
Anal Chem
December 2024
Department of Chemistry, National Demonstration Centre for Experimental Chemistry Education, Yanbian University, Yanji City 133002, Jilin Province, China.
Generally, the traditional stationary phase for liquid chromatography is the key part, but with an in situ immutable property, leading to many separation limitations. Based on the former exploration of photosensitive gas chromatography, we successfully prepared a photosensitive monolithic capillary silica column with high light transmission, taking advantage of the reversible cis-trans isomerism of azobenzene. And the cis-trans isomerism has launched an effective, reversible, and precise control on the liquid chromatographic retention behavior just by photoinduction according to the theoretical basis of a good correlation between photoinduction time, -azobenzene ratio, and chromatographic retention factor () ( > 0.
View Article and Find Full Text PDFLipoCLEAN: A Machine Learning Filter to Improve Untargeted Lipid Identification Confidence.
Anal Chem
December 2024
Biosciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37830, United States.
In untargeted lipidomics experiments, putative lipid identifications generated by automated analysis software require substantial manual filtering to arrive at usable high-confidence data. However, identification software tools do not make full use of the available data to assess the quality of lipid identifications. Here, we present a machine-learning-based model to provide coherent, holistic quality scores based on multiple lines of evidence.
View Article and Find Full Text PDFInvestigation of the interaction between collagen and furan derivatives during the heating process via multidimensional spectroscopy and GC-MS technology.
Food Chem
December 2024
College of Food Science and Technology, Bohai University, Jinzhou 121013, China. Electronic address:
The flavor retention plays a critical role in the presence of rich flavor profile of meat products. However, the interaction between collagen and furan derivatives has not been previously reported. In this study, the interaction between collagen and furan derivatives during heating was investigated using multidimensional spectroscopy and gas chromatography-mass spectrometry (GC-MS).
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