Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s10067-021-05838-w | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Recent Advances in Managing Ankylosing Spondylitis with Andersson Lesion: A Clinical Overview and Case Report.
J Orthop Case Rep
January 2025
Department of Orthopaedics, Saveetha Institute of Medical and Technical Sciences, Chennai, Tamil Nadu, India.
Introduction: Ankylosing spondylitis (AS) is a chronic inflammatory disorder that primarily affects the spine and sacroiliac joints, leading to pain, stiffness, and progressive thoracolumbar kyphotic deformity. A key complication in advanced AS is the development of Andersson lesions (AL), degenerative vertebral lesions resulting from the disease's progression. These lesions can cause significant mechanical pain, often mistaken for the chronic discomfort associated with AS.
View Article and Find Full Text PDFElevated Calprotectin Levels Reveal Loss of Vascular Pattern and Atrophy of Villi in Ileum by Digital Chromoendoscopy and Magnification Colonoscopy in Patients with Spondyloarthritis Without Having Inflammatory Bowel Disease.
Diagnostics (Basel)
November 2024
Cellular and Molecular Immunology Group-InmuBo, School of Dentistry, Universidad El Bosque, Av. Cra 9 No. 131 A-02, Bogotá 110121, Colombia.
Article Synopsis
- The study aimed to find a link between fecal calprotectin (FC) levels and intestinal inflammation in patients with spondyloarthritis (SpA) who do not have inflammatory bowel disease.
- Out of 180 SpA patients, approximately 27% exhibited positive fecal calprotectin and about 16% showed high levels, with significant associations found between higher FC levels and measures of disease activity and abdominal symptoms.
- The results suggest that elevated FC levels, especially in patients showing loss of vascular pattern in the ileum, could serve as a useful biomarker for managing SpA, indicating a common immune response related to chronic inflammation.
Comparative study of two laboratory techniques for the detection of HLA-B27 in patients with axial spondyloarthritis: a cross-sectional analysis.
Adv Rheumatol
May 2024
Serviço de Reumatologia, Hospital de Clínicas de Porto Alegre - HCPA, Faculdade de Medicina da Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2350, Porto Alegre, Rio Grande do Sul, 90035-903, Brazil.
Background: The diagnostic and prognostic relevance of Human Leukocyte Antigen B-27 (HLA-B27) in Axial Spondyloarthritis (AxSpA) is undeniable, with 70% of Ankylosing Spondylitis (AS) patients carrying the B27 gene, contrasted with a mere 4.35% in the general population. Flow cytometry (FC) and Polymerase Chain Reaction (PCR) have emerged as the predominant techniques for routine HLA-B27 typing.
View Article and Find Full Text PDF[HLA genotypes associated with gastrointestinal symptoms in patients with spondyloarthritis without inflammatory bowel disease].
Rev Alerg Mex
February 2024
Universidad Militar Nueva Granada, School of Medicine, Clinical Immunology Group, Bogotá, Colombia.
Objective: This study aimed to establish the association between HLA-A, B, DR genotypes and gastrointestinal variables in patients with SpA without inflammatory bowel disease (IBD).
Methods: Retrospective study of 91 patients with SpA and 401 healthy controls, with typing by Illumina Sequencing/PacBio and LIFECODES HLA-PCR/SSO multiplex sequencing technology. The presence of gastrointestinal symptoms was evaluated by administering a survey, and those who presented 2 or more symptoms were taken for clinical evaluation by rheumatology and gastroenterology, colonoscopy and histopathological study.
Association between HLA-B*27:04 and genetic susceptibility to ankylosing spondylitis in Hunan Province.
Zhong Nan Da Xue Xue Bao Yi Xue Ban
December 2023
Department of Immunology, School of Basic Medical Sciences, Central South University, Changsha 410013.
Objectives: Human leukocyte antigen (HLA) B27 is a susceptibility allele of ankylosing spondylitis (AS), and HLA-B27 antigen typing is an important indicator for clinical diagnosis of AS, but current typing methods such as sequence specific primer polymerase chain reaction (PCR-SSP) still possess limitation. Therefore, this study aims to analyze the correlation between B27 subtypes and susceptibility to AS in Hunan Province by applying high-resolution polymerase chain reaction-sequence-based typing (PCR-SBT).
Methods: Peripheral blood of 116 patients with suspected AS (suspected AS group) and 121 healthy volunteers (control group) admitted to the Second Xiangya Hospital from January 2020 to December 2020 were collected for HLA-B genotyping by PCR-SBT.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!