AI Article Synopsis
- The study aimed to explore outcomes of uveitis linked to Vogt-Koyanagi-Harada (VKH) disease in children aged 16 and under.
- Out of 244 identified patients with VKH disease, 38 were children, showing distinct differences in disease presentation and severity; chronic recurrent cases had more severe inflammation and higher complication rates.
- Results revealed that a significant majority (92.4%) of children with initial-onset acute VKH achieved better visual acuity compared to just 70.6% of those with chronic recurrent VKH, indicating worse outcomes for chronic cases.
Article Abstract
Purpose: To investigate the outcomes of uveitis associated with Vogt-Koyanagi-Harada (VKH) disease in pediatric age group (aged 16 years and under).
Methods: A retrospective review of patients with VKH disease.
Results: Among the 244 patients identified, 38 (76 eyes) were children. Among them, five had insulin-dependent diabetes mellitus. 21 presented with initial-onset acute disease and 17 with chronic recurrent disease. The mean follow-up period was 59.1 months. At presentation, chronic recurrent disease was associated with more severe inflammation as indicated by the presence of mutton-fat keratic precipitates ( < .001), iris nodules ( = .005) and posterior synechiae ( < .001). During follow-up, the rate of complications was higher in children with chronic recurrent disease compared with initial-onset acute disease ( < .001). 92.4% of the eyes with initial-onset acute disease achieved a final visual acuity of ≥20/40 compared with 70.6% of the eyes with chronic recurrent disease ( = .013).
Conclusions: Chronic recurrent VKH disease in children is associated with worse outcomes.
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| http://dx.doi.org/10.1080/09273948.2021.1933074 | DOI Listing |
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