AI Article Synopsis
- Autoimmune thyroid disease (AITD) is frequently observed in diabetes mellitus (DM) patients, and this study explores its impact on diabetic kidney disease (DKD) in patients with type 1 diabetes (DM1).
- The research analyzed various health parameters of 144 DM1 patients, revealing significant differences in kidney function markers among those with DKD, including lower fT3 levels among DKD patients.
- Although DM1 patients with AITD showed lower creatinine levels, the study found no significant link between AITD and the occurrence of DKD, indicating a need for further research on these relationships.
Article Abstract
Autoimmune thyroid disease (AITD) is more common among diabetes mellitus (DM) patients and may impact its microvascular complications. The present study aimed to assess the relationship between AITD and the prevalence of diabetic kidney disease (DKD) in patients with diabetes mellitus type 1 (DM1). Anthropometric parameters, parameters of metabolic control of DM, thyreometabolic status, and the UACR were assessed. DKD was diagnosed if patients' UACR level was ≥30 mg/g or eGFR level was <60 mL/min. This study involved 144 patients with DM1 aged 36.2 ± 11.7 years: 49 men and 95 women. Significant differences in creatinine, eGFR, and UACR levels were found in patients with DKD. fT3 concentration was significantly lower among DKD patients. A significantly higher probability of DKD was found in DM1 patients with lower fT3 levels. Patients with DM1 and AITD had significantly lower creatinine levels than the control group. However, the study did not show any significant relationship between AITD and the occurrence of DKD in patients with DM1. Significantly lower fT3 concentrations in DKD patients may be caused by metabolic disorders in the course of DKD and require further cohort studies in a larger population of patients with DM1 and AITD.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8218549 | PMC |
| http://dx.doi.org/10.1515/biol-2021-0064 | DOI Listing |
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