Heyde's syndrome (HS) is described as the association between recurrent bleeding from angiodysplasia of the gastrointestinal tract and aortic stenosis. Aortic valve replacement has been reported to stop the bleeding. In unfit patients, the options available are interventional or conservative management. We hereby report an elderly obese patient with severe comorbidity with complicated HS involving a narrow aortic root. She underwent left ventricular outlet myomectomy and aortic root replacement to promote better forward flow and prevent restenosis and recurrence of symptoms. She was discharged home symptom-free despite being on coumadin anticoagulants.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8143720PMC
http://dx.doi.org/10.37616/2212-5043.1237DOI Listing

Publication Analysis

Top Keywords

heyde's syndrome
8
aortic root
8
syndrome enigma
4
enigma heyde's
4
syndrome described
4
described association
4
association recurrent
4
recurrent bleeding
4
bleeding angiodysplasia
4
angiodysplasia gastrointestinal
4

Similar Publications

Importance: Heyde syndrome is the cooccurrence of aortic stenosis and gastrointestinal bleeding secondary to vascular lesions, including angiodysplasias. Several studies have demonstrated cessation of gastrointestinal bleeding after transcatheter aortic valve implantation (TAVI), but the etiology and effects on vascular lesions are largely unknown.

Objective: To examine the associations of TAVI with gastrointestinal vascular lesions and identify factors associated with recovery among patients with iron deficiency anemia and severe aortic stenosis.

View Article and Find Full Text PDF

Heyde Syndrome Unveiled: A Case Report with Current Literature Review and Molecular Insights.

Int J Mol Sci

October 2024

Center for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, Serbia.

Heyde syndrome, marked by aortic stenosis, gastrointestinal bleeding from angiodysplasia, and acquired von Willebrand syndrome, is often underreported. Shear stress from a narrowed aortic valve degrades von Willebrand factor multimers, leading to angiodysplasia formation and von Willebrand factor deficiency. This case report aims to raise clinician awareness of Heyde syndrome, its complexity, and the need for a multidisciplinary approach.

View Article and Find Full Text PDF
Article Synopsis
  • Heyde syndrome consists of anemia, aortic valve stenosis, and acquired von Willebrand syndrome, yet it remains under-recognized in clinical settings.
  • A 70-year-old woman with severe iron-deficiency anemia and aortic stenosis was diagnosed with Heyde syndrome after extensive testing that ruled out other bleeding sources.
  • Aortic valve replacement surgery improved her anemia and symptoms, highlighting the need for awareness of Heyde syndrome in cases of unexplained anemia, particularly when associated with aortic stenosis.
View Article and Find Full Text PDF

Recent advances in the treatment of refractory gastrointestinal angiodysplasia.

United European Gastroenterol J

October 2024

Sorbonne University, Center for Digestive Endoscopy, Saint Antoine Hospital, AP HP, Paris, France.

Article Synopsis
  • - Gastrointestinal angiodysplasia (GIA) is a prevalent, acquired vascular issue in the digestive tract, often leading to significant bleeding and requiring repeat treatments such as transfusions or endoscopies.
  • - Recent studies focus on non-endoscopic options for treating refractory GIA, highlighting the effectiveness of aortic valve replacement in cases of Heyde syndrome and the use of anti-angiogenic drugs like Octreotide and Thalidomide.
  • - Future advancements in understanding the underlying mechanisms of GIA could pave the way for the development of new, targeted treatments.
View Article and Find Full Text PDF

Heyde's syndrome (HS) represents an association between aortic stenosis and intestinal angiodysplasias, and it has been demonstrated that acquired von Willebrand disease plays a pivotal role in the pathophysiology of this syndrome. In patients with HS, von Willebrand factor deficiency represents an additional risk factor, further contributing to the risk of bleeding and anemia. We present the case of an 86-year-old patient diagnosed with HS and von Willebrand deficiency in 2018.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!