AI Article Synopsis
- The study aimed to compare critically ill children with multisystem inflammatory syndrome (MIS-C), focusing on those who were PCR-positive versus PCR-negative but antibody-positive.
- Conducted at a pediatric intensive care unit in India, the analysis included 17 children with severe MIS-C, revealing that those who were PCR-negative were older and had higher D-dimer levels.
- Most children received intensive care and steroid therapy; out of the 17, 14 survived, indicating that early recognition and treatment significantly improve outcomes for MIS-C patients.
Article Abstract
Objectives: To compare the clinical profile, treatment, and outcomes of PCR-positive and PCR-negative antibody-positive critically ill children with multisystem inflammatory syndrome (MIS-C).
Methods: This retrospective observational study was done at a tertiary care coronavirus disease 19 (COVID-19) pediatric intensive care unit in India. The baseline characteristics, clinical profile, treatment, and outcomes in seventeen critically ill children diagnosed with MIS-C were analyzed from 1 July to 31 October, 2020.
Results: Sixteen out of 17 children presented with hypotensive shock and respiratory distress. Mean (SD) age of PCR-negative antibody-positive and PCR-positive children was 11 (4.4) and 5 (3.7) years, respectively (P=0.007). The former group had significantly higher mean (SD) D-dimer levels [16,651 (14859) ng/mL vs 3082 (2591) ng/mL; P=0.02]. All received intensive care management and steroid therapy; 7 children received intravenous immunoglobulin. 14 children survived and 3 died.
Conclusions: The outcome of children with MIS-C was good if recognized early and received intensive care.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8549596 | PMC |
| http://dx.doi.org/10.1007/s13312-021-2330-3 | DOI Listing |
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