AI Article Synopsis
Article Abstract
Flow-sensitive four-dimensional Cardiovascular Magnetic Resonance Imaging (4D Flow CMR) has increasingly been utilised to characterise patients' blood flow, in association with patiens' state of health and disease, even though spatial and temporal resolutions still constitute a limit. Computational fluid dynamics (CFD) is a powerful tool that could expand these information and, if integrated with experimentally-obtained velocity fields, would enable to derive a large variety of the flow descriptors of interest. However, the accuracy of the flow parameters is highly influenced by the quality of the input data such as the anatomical model and boundary conditions typically derived from medical images including 4D Flow CMR. We previously proposed a novel approach in which 4D Flow CMR and CFD velocity fields are integrated to obtain an Enhanced 4D Flow CMR (EMRI), allowing to overcome the spatial-resolution limitation of 4D Flow CMR, and enable an accurate quantification of flow. In this paper, the proposed approach is validated in a U bend channel, an idealised model of the human aortic arch. The flow patterns were studied with 4D Flow CMR, CFD and EMRI, and compared with high resolution 2D PIV experiments obtained in pulsatile conditions. The main strengths and limitations of 4D Flow CMR and CFD were illustrated by exploiting the accuracy of PIV by comparing against PIV velocity fields. EMRI flow patterns showed a better qualitative and quantitative agreement with PIV results than the other techniques. EMRI enables to overcome the experimental limitations of MRI-based velocity measurements and the modelling simplifications of CFD, allowing an accurate prediction of complex flow patterns observed experimentally, while satisfying mass and momentum balance equations.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s10439-021-02811-1 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Feasibility of 4D-flow CMR for hemodynamic characterization in hypertrophic cardiomyopathy after septal myectomy with and without anterior mitral valve leaflet extension.
Interdiscip Cardiovasc Thorac Surg
December 2024
Department of Cardiothoracic Surgery, Erasmus University Medical Center, Rotterdam, Netherlands.
Objectives: The common surgical treatment in patients with obstructive hypertrophic cardiomyopathy (HCM) is septal myectomy. This involves resection of a segment of the myocardial septum and can be performed with and without concomitant anterior mitral valve leaflet extension (AMVLE). While both approaches have satisfying clinical outcomes, there is a lack of data regarding the added value of concomitant AMVLE.
View Article and Find Full Text PDFCardiac Functional Assessment by Magnetic Resonance Imaging.
Cardiol Discov
December 2024
Department of Magnetic Resonance Imaging, Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
The assessment of cardiac function using echocardiography has gained a strong foothold in clinical practice. Cardiac magnetic resonance (CMR) imaging harbors distinct advantages over echocardiography, as it is not affected by limitations of acoustic windows and operator dependence. CMR is also designed to non-invasively assess cardiac morphology, ventricular geometry, myocardial wall motion, and intra-cardiac flow quantification without the use of ionizing radiation.
View Article and Find Full Text PDFAssessing microvascular dysfunction and predicting long-term prognosis in patients with cardiac amyloidosis by CMR quantitative stress perfusion.
J Cardiovasc Magn Reson
December 2024
Department of Radiology, The Second Xiangya Hospital, Central South University, Changsha, China; Clinical Research Center for Medical Imaging in Hunan Province, Changsha, China. Electronic address:
Background: Cardiac involvement in light chain (AL) amyloidosis is the main determinant of prognosis. Amyloid can be deposited in the extracellular space and cause an increase in extracellular volume (ECV). At the same time, amyloid can also be deposited in the wall of small vessels and cause microvascular dysfunction.
View Article and Find Full Text PDFSeascape Genomics of the Smooth Hammerhead Shark Reveals Regional Adaptive Clinal Variation.
Ecol Evol
December 2024
Molecular Breeding and Biodiversity Group, Department of Genetics Stellenbosch University Stellenbosch South Africa.
Globally, hammerhead sharks have experienced severe declines owing to continued overexploitation and anthropogenic change. The smooth hammerhead shark remains understudied compared to other members of the family Sphyrnidae. Despite its vulnerable status, a comprehensive understanding of its genetic landscape remains lacking in many regions worldwide.
View Article and Find Full Text PDFImprove myocardial strain estimation based on deformable groupwise registration with a locally low-rank dissimilarity metric.
BMC Med Imaging
December 2024
National Engineering Research Center of Advanced Magnetic Resonance Technologies for Diagnosis and Therapy, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Background: Current mainstream cardiovascular magnetic resonance-feature tracking (CMR-FT) methods, including optical flow and pairwise registration, often suffer from the drift effect caused by accumulative tracking errors. Here, we developed a CMR-FT method based on deformable groupwise registration with a locally low-rank (LLR) dissimilarity metric to improve myocardial tracking and strain estimation accuracy.
Methods: The proposed method, Groupwise-LLR, performs feature tracking by iteratively updating the entire displacement field across all cardiac phases to minimize the sum of the patchwise signal ranks of the deformed movie.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!