Beginning with the observation that a good integration of soma and psyche is often missing in our work with severely disturbed analysands, two concepts are discussed that focus constellations of bodily encoded unconscious material, which needs a specific form of working-through. The concept of encapsulated body engrams referring to defence structures revolving around the inhibition or disorganization of an affective bodily impulse is outlined. The imbalance arising this way is perceived as a foreign body within the body-self. These engrams are repetitive and are not susceptible to symbolic transformation. Parallels between the encapsulated body engram, the autistic objects (Tustin, F. 1980. "Autistic Objects." 27: 27-39) and Freud's theory of inhibition (Freud, S. 1926. "Inhibitions, Symptoms and Anxiety." 20: 77-175) are discussed. To unblock encapsulated engrams, body feelings emerging in the chain of associations are understood as attempts to communicate. In a process called somatic narration these perceptions are contextualized with other bodily sensations. The working-through of this material in transference and countertransference is described in the light of Lombardi's concepts (Lombardi, R. 2017. . New York: Routledge). Two case reports precede the theoretical discussion.
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http://dx.doi.org/10.1080/00207578.2021.1927044 | DOI Listing |
Front Immunol
January 2025
Department of Medical Laboratory, Affiliated Hospital of Jiujiang University, Jiujiang, Jiangxi, China.
Lactate, long viewed as a byproduct of glycolysis and metabolic waste. Initially identified within the context of yogurt fermentation, lactate's role extends beyond culinary applications to its significance in biochemical processes. Contemporary research reveals that lactate functions not merely as the terminal product of glycolysis but also as a nexus for initiating physiological and pathological responses within the body.
View Article and Find Full Text PDFPharmaceutics
January 2025
Department of Medicinal Plants, Faculty of Agriculture and Natural Resources, Arak University, Arak 38156-8-8349, Iran.
In the 21st century, thanks to advances in biotechnology and developing pharmaceutical technology, significant progress is being made in effective drug design. Drug targeting aims to ensure that the drug acts only in the pathological area; it is defined as the ability to accumulate selectively and quantitatively in the target tissue or organ, regardless of the chemical structure of the active drug substance and the method of administration. With drug targeting, conventional, biotechnological and gene-derived drugs target the body's organs, tissues, and cells that can be selectively transported to specific regions.
View Article and Find Full Text PDFPharmaceutics
December 2024
Ningbo No. 2 Hospital, Ningbo 315099, China.
The two obstacles for treating glioma are the skull and the blood brain-barrier (BBB), the first of which forms a physical shield that increases the difficulties of traditional surgery or radiotherapy, while the latter prevents antitumor drugs reaching tumor sites. To conquer these issues, we take advantage of the high penetrating ability of sonodynamic therapy (SDT), combined with a novel nanocomplex that can easily pass the BBB. Through ultrasonic polymerization, the amphiphilic peptides (CGRRGDS) were self-assembled as a spherical shell encapsulating a sonosensitizer Rose Bengal (RB) and a plant-derived compound, sulforaphane (SFN), to form the nanocomplex SFN@RB@SPM.
View Article and Find Full Text PDFMolecules
January 2025
Department of Physical Pharmacy, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, 40-055 Katowice, Poland.
Human serum albumin (HSA) plays a fundamental role in the human body, including the transport of exogenous and endogenous substances. HSA is also a biopolymer with a great medical and pharmaceutical potential. Due to nontoxicity and biocompatibility, this protein can be used as a nanocarrier.
View Article and Find Full Text PDFMaterials (Basel)
January 2025
University Centre for Research and Development (UCRD), Department of Physics, Chandigarh University, Mohali 140413, Punjab, India.
Novel studies on typical synthesized magnetite nanoparticles were encapsulated into a poly (butylene succinate)/poly (ethylene glycol) copolymer (PBS-PEG). PBS was chosen because of its biocompatibility characteristics necessary for biomedical applications. PEG, as part of the macromolecular structure, increases the hybrid system's solubility in an aqueous environment, increasing the circulation time of the material in the bloodstream.
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