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Cardiac light-chain deposition disease and hints at diagnosing: a case report.
Eur Heart J Case Rep
February 2023
Department of Rheumatology, Kanazawa University Hospital, 13-1, Takara-machi, Kanazawa, Ishikawa 920-8641, Japan.
Article Synopsis
- Light-chain deposition disease (LCDD) is a rare systemic condition that involves abnormal light-chain deposits in various organs, leading to potential organ failure, often associated with Bence-Jones type monoclonal gammopathy.
- A case study of a 65-year-old man with end-stage renal disease revealed he had cardiac LCDD instead of the initially suspected dialysis-associated cardiomyopathy, despite negative tests for cardiac amyloidosis.
- There is a need for greater awareness among clinicians about the risk of cardiac LCDD, particularly in patients with heart failure and renal issues, as it may go undetected unless thoroughly investigated.
Patients with cardiac amyloidosis have a greater neurohormonal activation than those with non-amyloidotic heart failure.
Amyloid
December 2021
Institute of Life Sciences, Scuola Superiore Sant'Anna, Pisa, Italy.
Background: Neurohormonal activation has never been investigated in patients with cardiac amyloidosis (CA).
Methods: Forty-seven patients with amyloid light-chain (AL)-CA and 61 with transthyretin (ATTR)-CA were matched to non-amyloidotic heart failure (HF) patients based on age, sex, left ventricular ejection fraction ranges, renal function and HF therapies. N-terminal pro-B-type natriuretic peptide (NT-proBNP), norepinephrine and renin were dosed.
Light chain deposition disease presenting as an atrial mass: a case report and review of literature.
Cardiovasc Pathol
December 2021
Department of Pathology, Fairfield Medical Center, Lancaster, Ohio. Electronic address:
Light chain deposition disease (LCDD) also known as nonamyloidotic immunoglobulin deposition disease is a rare systemic disorder due to the abnormal deposition of immunoglobulin in multiple organs caused by the clonal proliferation of B lymphocytes and plasma cells. Renal involvement is the most common with cardiac manifestations being the most common extra renal presentation of the disease. Renal involvement is not always associated with LCDD.
View Article and Find Full Text PDFNonamyloidotic light chain deposition cardiomyopathy.
Eur Heart J Cardiovasc Imaging
October 2021
Department of Cardiology, Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, University of Basel, Petersgraben 4, CH-4031 Basel, Switzerland.
Nonamyloidotic Light Chain Cardiomyopathy: The Arrhythmogenic Magnetic Resonance Pattern.
Circulation
April 2016
From Department of Cardiac, Thoracic and Vascular Sciences (M.D.L., M.F., F.M., A.C., L.C., G. Tarantini, S.I., G. Thiene, M.V., A.A., M.P.M.), Radiology (B.G.), and Hematology and Clinical Immunology Unit (F.A.), University of Padua, Padua, Italy.
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