AI Article Synopsis
- Osteoporosis is a bone disease that affects the composition of bone tissue and increases fracture risk, and antiresorptive therapy is a common treatment method focused on controlling drug delivery to reduce side effects.
- Researchers explored the use of layered double hydroxide (LDH) composites mixed with poly (ε-caprolactone) (PCL) to achieve controlled release of the drug Alendronate.
- Findings revealed that higher amounts of LDH in the PCL matrix lead to better and more controlled release of Alendronate, enhancing cell viability and mineralization, making it a promising candidate for osteoporosis treatment.
Article Abstract
Background: Osteoporosis is a bone disease alters the amount and variety of proteins in bone tissue and increases the potential of bone fracture. Antiresorptive therapy is one of the most popular treatment methods for osteoporosis. To reduce side effects and enhance the bioavailability of drug agents, the controlled delivery of drug is commonly utilized.
Objectives: We investigated the controlled release of Alendronate in different composites of layered double hydroxide (LDH) using poly (ε-caprolactone) (PCL) as a matrix.
Materials And Methods: We prepared different microsphere composites of ALD intercalated in various amounts of LDH, using PCL as a matrix. The controlled release of ALD from these composites is subsequently investigated. Samples are characterized and cell cytotoxicity, attachment, osteogenic activity including alkaline phosphatase activity and mineralization are examined using MG-63 human osteosarcoma cells.
Results: The results showed that the release of ALD is more desirable and controlled in the samples having a higher amount of LDH incorporated into the PCL matrix. MG63 cells show a significant increase in viability, attachment, and mineralization while alkaline phosphatase activity remains almost at a constant level after 3 weeks.
Conclusions: Overall, the findings showed that by incorporation of 15 wt% of LDH, the composite microsphere is capable of holding the antiresorptive drug longer and release it in a more controlled manner. This is an advantageous and promising characteristic for a carrier that could be used as a potential candidate for osteoporosis treatment.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8217540 | PMC |
| http://dx.doi.org/10.30498/IJB.2021.2490 | DOI Listing |
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