Chiral Phosphoric Acid Promoted Chiral 1H NMR Analysis of Atropisomeric Quinolines.

Front Chem

College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou, China.

Published: June 2021

An efficient enantioselective NMR analysis of atropisomeric quinolines in the promotion of chiral phosphoric acid is described, in which a variety of racemic 4-aryl quinolines were well-recognized with up to 0.17 ppm ΔΔδ value. Additionally, the optical purities of different nonracemic substrates could be evaluated fast via NMR analysis with high accuracy.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8222546PMC
http://dx.doi.org/10.3389/fchem.2021.672704DOI Listing

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