High LET-Like Radiation Tracks at the Distal Side of Accelerated Proton Bragg Peak.

Front Oncol

Department of Environmental & Radiological Health Sciences, Colorado State University, Fort Collins, CO, United States.

Published: June 2021

AI Article Synopsis

  • Proton therapy is an advanced cancer treatment using hadron radiotherapy, which targets solid tumors with protons that have higher biological effectiveness compared to X-rays.
  • Research shows that proton radiation's cytotoxic effects peak at the Bragg peak, with extended effects observed a few millimeters beyond it, indicating potential for cellular damage and repair difficulties in those areas.
  • The study revealed that particle track-like structures in the post-Bragg peak region can lead to significant DNA damage, complicating the effectiveness of proton therapy and potentially causing side effects.

Article Abstract

Proton therapy is a type of hadron radiotherapy used for treating solid tumors. Unlike heavy charged elements, proton radiation is considered to be low LET (Linear Energy Transfer) radiation, like X-rays. However, the clinical SOBP (Spread Out Bragg Peak) proton radiation is considered to be higher in relative biological effectiveness (RBE) than both X-ray and their own entrance region. The RBE is estimated to be 1.1-1.2, which can be attributed to the higher LET at the SOBP region than at the entrance region. In order to clarify the nature of higher LET near the Bragg peak of proton radiation and its potential cytotoxic effects, we utilized a horizontal irradiation system with CHO cells. Additionally, we examined DNA repair mutants, analyzed cytotoxicity with colony formation, and assessed DNA damage and its repair with -H2AX foci assay in a high-resolution microscopic scale analysis along with the Bragg peak. Besides confirming that the most cytotoxic effects occurred at the Bragg peak, extended cytotoxicity was observed a few millimeters after the Bragg peak. -H2AX foci numbers reached a maximum at the Bragg peak and reduced dramatically after the Bragg peak. However, in the post-Bragg peak region, particle track-like structures were sporadically observed. This region contains foci that are more difficult to repair. The peak and post-Bragg peak regions contain rare high LET-like radiation tracks and can cause cellular lethality. This may have caused unwanted side effects and complexities of outputs for the proton therapy treatment.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8222778PMC
http://dx.doi.org/10.3389/fonc.2021.690042DOI Listing

Publication Analysis

Top Keywords

bragg peak
32
peak proton
12
proton radiation
12
peak
11
high let-like
8
let-like radiation
8
radiation tracks
8
bragg
8
proton therapy
8
radiation considered
8

Similar Publications

The effects of mechanical vibrations on control system stability could be significant in control systems designed on the assumption of rigid-body dynamics, such as launch vehicles. Vibrational loads can also cause damage to launch vehicles due to fatigue or excitation of structural resonances. This paper investigates a method to control structural vibrations in real time using a finite number of strain measurements from a fiber Bragg grating (FBG) sensor array.

View Article and Find Full Text PDF

Adhesive joining has the severe limitation that damages/defects developed in the bondline are difficult to assess. Conventional non-destructive examination (NDE) techniques are adequate to reveal disbonding defects in fabrication and delamination near the end of service life but are not helpful in detecting and monitoring in-service degradation of the joint. Several techniques suitable for long-term joint integrity monitoring are proposed.

View Article and Find Full Text PDF

Background And Purpose: Radiotherapy induces tumor cell killing by generating DNA double strand breaks (DSBs). The effectiveness of radiotherapy is significantly influenced by the repair of DSBs, which counteracts this lethal effect. Current investigations are focused on determining whether non-homologous end joining (NHEJ) or homologous recombination is the predominant repair pathway following proton and photon radiation.

View Article and Find Full Text PDF

A wavelength demodulation method for ultra-short fiber Bragg grating (US-FBG) sensors based on an arrayed waveguide grating (AWG) and a convex optimization algorithm is proposed and demonstrated. Instead of measuring the output power ratio of the two adjacent AWG channels as previously done, in this work the wavelength demodulation is realized by reconstructing the US-FBG spectrum. The principle of spectral reconstruction involves using an AWG to sample the spectral information of US-FBG and constructing underdetermined matrix equations with the obtained prior information on transmission responses and the detected output power from multiple AWG channels.

View Article and Find Full Text PDF

Background: A passive dosimeter framework for the measurement of dose in carbon ion beams has yet to be characterized or implemented for regular use.

Purpose: This work determined the dose calculation correction factors for absorbed dose in thermoluminescent dosimeters (TLDs) in a therapeutic carbon ion beam. TLD could be a useful tool for remote audits, particularly in the context of clinical trials as new protocols are developed for carbon ion radiotherapy.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!