Introduction: Hippocampal sclerosis is the most frequent pathological substrate in drug resistant temporal lobe epilepsy (TLE). Recently 4 types of hippocampal sclerosis (HS) have been defined in a task force by the International League Against Epilepsy (ILAE), based on patterns of cell loss in specific hippocampal subfields. Type 1 HS is most frequent and has the most favorable outcome after epilepsy surgery. We hypothesized that volume loss in specific hippocampal subfields determined by automated volumetry of high resolution MRI would correspond to cell loss in histological reports.
Material And Methods: In a group of well characterized patients with drug resistant TLE (N = 26 patients, 14 with right-sided focus, 12 with left-sided focus) volumes of the right and left hippocampus and the hippocampal subfields CA1, CA2 + 3, CA4 and dentate gyrus (DG) were estimated automatically using FreeSurfer version 6.0 from high-resolution cerebral MRI and compared to a large group of healthy controls (N = 121). HS subtype classification was attempted based on histological reports.
Results: Volumes of the whole hippocampus and all investigated hippocampal subfields (CA1, CA2 + 3, CA4 and DG) were significantly lower on the ipsilateral compared the contralateral side (p < 0.001) and compared to the healthy controls (p < 0.001). Conversely, whole hippocampal and hippocampal subfield volumes were not significantly different from healthy control values on the contralateral side. In 12 of 20 patients the pattern of hippocampal volume loss in specific subfields was in accordance with HS types from histology. The highest overlap between automated MRI and histology was achieved for type 1 HS (in 10 of 12 cases).
Conclusion: The automated volumetry of hippocampal subfields, based on high resolution MRI, may have the potential to predict the pattern of cell loss in hippocampal sclerosis before operation.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.eplepsyres.2021.106692 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Spatial and sex‐specific hippocampal proteomic analysis of an early Alzheimer’s disease mouse model using MALDI‐imaging.
Alzheimers Dement
December 2024
Neurophysiology & Behaviour Lab, University of Castilla‐La Mancha, Ciudad Real, Spain
Background: A key neuropathological feature in the early stages of Alzheimer's disease (AD) involves hippocampal dysfunction arising from the accumulation of amyloid‐β (Aβ). Previously, our laboratory identified a shift in the synaptic plasticity long term potentiation (LTP)/long term depression (LTD) induction threshold, leading to memory deficits in a non‐transgenic murine model of early AD generated by intracerebroventricular (icv.) injections Aβ oligomers (oAβ), one of the most predominant pathogenetic factors in initial stages of the disease.
View Article and Find Full Text PDFThe atrophy of specific amygdala subnuclei is associated with temporal tauopathy in preclinical AD individuals.
Alzheimers Dement
December 2024
Institute of Neuroscience ‐ UCLouvain, Brussels, Belgium
Background: In AD, tauopathy and atrophy start in the mesiotemporal lobe, including the amygdala‐hippocampal complex. Until recently, subnuclei and subfields within these structures were indistinguishable in‐vivo. FreeSurfer 7.
View Article and Find Full Text PDFBackground: Older adults with type 2 diabetes (T2D) are more likely to develop Alzheimer’s disease (AD) due to impaired brain metabolism. Although the underlying mechanisms of this relationship are largely unknown, lower levels of brain‐derived neurotrophic factor (BDNF) –which promotes hippocampal neurogenesis in adulthood– and atrophy of the hippocampus are evident in patients with T2D and dementia, possibly linking the two conditions. The hippocampus is comprised of multiple subfields, each with their respective functions, cellular composition, and age‐related sensitivity.
View Article and Find Full Text PDFAssociation of Blood Pressure Mean and Variability with Hippocampal Subfield Volumes in Cerebral Amyloid Angiopathy with Mild Cognitive Symptoms.
Alzheimers Dement
December 2024
Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Background: The interaction between Alzheimer's pathology and cerebral amyloid angiopathy (CAA), a common cerebral small vessel disease, plays a crucial role in cognitive impairment development in older adults. Recent studies suggest that increased blood pressure (BP) variability may affect subclinical vascular disease and cognitive decline. However, it is currently unknown whether a particular BP profile is linked to hippocampal subfield volumes, which are a significant feature of cognitive decline in neurodegenerative diseases.
View Article and Find Full Text PDFTDP‐43 association with Subiculum and CA1 Hippocampal Subfield Atrophy in Primary Age‐Related Tauopathy.
Alzheimers Dement
December 2024
Mayo Clinic, Rochester, MN, USA
Background: The TAR DNA‐binding protein of 43 kDa (TDP‐43) is linked to hippocampal volume loss and faster rates of hippocampal atrophy in Alzheimer's disease and primary age‐related tauopathy (PART). Hence, TDP‐43 is becoming an important player in age‐related neurodegeneration. To advance our understanding of TDP‐43 effect on hippocampus, we conducted an imaging‐pathological study to determine which specific hippocampal subfields are affected by TDP‐43 in cases of PART.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!