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Unveiling the hidden trajectories of gastrointestinal disease in systemic sclerosis.
Rheumatology (Oxford)
December 2024
Division of Rheumatology, Scleroderma Unit, Careggi University Hospital, Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Unveiling the hidden causal links: skin flora and cutaneous melanoma.
Front Oncol
December 2024
Department of Dermatology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
Objective: The presence of skin flora (SF) has been identified as a significant factor in the onset and progression of cutaneous melanoma (CM). However, the vast diversity and abundance of SF present challenges to fully understanding the causal relationship between SF and CM.
Methods: A Two Sample Mendelian Randomization (TSMR) analysis was conducted to investigating the causal relationship between SF and CM.
MINOCA and Type 2 mycardial infarction: Unveiling the hidden differences.
Int J Cardiol
December 2024
Centro Cardiologico Monzino, I.R.C.C·S, Milan, Italy. Electronic address:
Unveiling the hidden network of STING's subcellular regulation.
Cell Syst
December 2024
Icahn Genomics Institute (IGI), Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Immunology & Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address:
A new study deconvolutes the systems-level control of the cGAS-STING pathway and identifies many novel regulators of STING biology. This was made possible by optical pooled screening (OPS), which enables high-dimensional imaging of millions of gene-edited cells, showcasing the future of CRISPR screening.
View Article and Find Full Text PDFUnveiling the hidden diversity and functional role of Chloroflexota in full-scale wastewater treatment plants through genome-centric analyses.
ISME Commun
January 2024
Microbial Ecology Laboratory, Department of Microbial Biochemistry and Genomic, Biological Research Institute "Clemente Estable", Avenida Italia 3318, 11600 Montevideo, CP, Uruguay.
The phylum Chloroflexota has been found to exhibit high abundance in the microbial communities from wastewater treatment plants (WWTPs) in both aerobic and anaerobic systems. However, its metabolic role has not been fully explored due to the lack of cultured isolates. To address this gap, we use publicly available metagenome datasets from both activated sludge (AS) and methanogenic (MET) full-scale wastewater treatment reactors to assembled genomes.
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