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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8261252 | PMC |
| http://dx.doi.org/10.1016/j.ymthe.2021.06.011 | DOI Listing |
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Drug Safety Research and Development, Pfizer Inc., Cambridge, MA, USA.
On August 18, 2021, the American Society of Gene and Cell Therapy (ASGCT) hosted a virtual roundtable on adeno-associated virus (AAV) integration, featuring leading experts in preclinical and clinical AAV gene therapy, to further contextualize and understand this phenomenon. Recombinant AAV (rAAV) vectors are used to develop therapies for many conditions given their ability to transduce multiple cell types, resulting in long-term expression of transgenes. Although most rAAV DNA typically remains episomal, some rAAV DNA becomes integrated into genomic DNA at a low frequency, and rAAV insertional mutagenesis has been shown to lead to tumorigenesis in neonatal mice.
View Article and Find Full Text PDFASGCT's new landscape reports: A comprehensive data resource.
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ASGCT 2021: Time to celebrate and expand.
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Novel vectors and approaches for gene therapy in liver diseases.
JHEP Rep
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Gene Therapy Area, Foundation for Applied Medical Research, University of Navarra, IdisNA, Pamplona, Spain.
Article Synopsis
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