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Ruthenium-Catalyzed Regioselective C(sp)-H Activation/Annulation of -(7-Azaindole)amides with 1,3-Diynes Using -Amino-7-azaindole as the ,-Bidentate Directing Group. | LitMetric

AI Article Synopsis

Article Abstract

The ruthenium(II)-catalyzed regioselective annulation of -(7-azaindole)amides with 1,3-diynes has been demonstrated. Bioactive -amino-7-azaindole has been used as a new bidentate directing group to furnish an array of 3-alkynylated isoquinolones. Furthermore, the developed protocol works efficiently for both aryl- and heteroaryl-substituted amides producing a range of pharmacologically useful 7-azaindole-based isoquinolones with a wide range of functionality.

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Source
http://dx.doi.org/10.1021/acs.joc.1c00759DOI Listing

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