AI Article Synopsis
- Acral persistent papular mucinosis is a rare form of lichen myxedematosus, characterized by small, whitish papules on the hands, as seen in a case study of a 41-year-old woman with a 5-year history of the condition.
- Histopathological examination showed distinct findings, including sparse collagen in the dermis and positive Alcian blue staining, confirming the diagnosis.
- Despite prior indications that tranilast may help manage this condition, the patient did not show improvement after two months of treatment, highlighting the need for further research on its effectiveness.
Article Abstract
Acral persistent papular mucinosis is a rare subtype of localized lichen myxedematosus. We report a case of a 41-year-old woman with acral persistent papular mucinosis. She had a 5-year history of multiple, scattered, whitish papules, on the back of both hands, of 2-5 mm in diameter. Histopathological examination revealed a focal, fairly circumscribed area with sparse collagen fibers in the upper and middle dermis. The circumscribed area was positively stained with Alcian blue. The papules were clinically and histologically diagnosed as acral persistent papular mucinosis. We also summarized 24 Japanese acral persistent papular mucinosis cases, including ours. Although acral persistent papular mucinosis occurs predominantly in women according to overseas reports, the male : female ratio is 5:7 in Japan. It has been reported that tranilast (N-[3,4-dimethoxycinnamoyl]-anthranilic acid) was effective in two Japanese cases. In our case, the patient had been treated with tranilast for 2 months without improvement. Further studies are required to confirm the efficacy of tranilast for acral persistent papular mucinosis.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/1346-8138.16043 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Acral Persistent Papular Mucinosis.
Mayo Clin Proc
January 2025
Department of Dermatology, Peking Union Medical College Hospital, State Key Laboratory of Complex Severe and Rare Diseases, Chinese Academy of Medical Science and Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases, Beijing, China. Electronic address:
Ends of the spectrum best practices for early detection and multidisciplinary management of acromegaly.
J Neurooncol
January 2025
Department of Neurosurgery, Medical College of Wisconsin, Hub for Collaborative Medicine, 8701 Watertown Plank Rd., Milwaukee, Wisconsin, 53226, USA.
Purpose: Acromegaly is characterized by an insidious clinical presentation and delayed diagnosis. Longer delays are associated with more comorbidities which can persist after treatment of the growth hormone-secreting pituitary adenoma (GH-PA). Surgery is the primary therapy of GH-secreting PA, which can lead to durable remission.
View Article and Find Full Text PDFErythema multiforme.
EClinicalMedicine
November 2024
GrIDIST (Groupe Infectiologie et Infections Sexuellement Transmissibles) Working Group of the French Society of Dermatology, France.
Unlabelled: Erythema multiforme is an inflammatory skin and mucosal disease mainly related to infectious agents such as Herpes simplex virus, , though it can also be "idiopathic". The characteristic skin lesions are typical or atypical acral raised target lesions. The oral mucosa can be affected, alone or in combination with other mucosal/cutaneous sites, sometimes causing extreme pain, severely impacting food intake, and warranting hospitalization.
View Article and Find Full Text PDFHereditary C1q Deficiency is Associated with Type 1 Interferon-Pathway Activation and a High Risk of Central Nervous System Inflammation.
J Clin Immunol
August 2024
Laboratory of Neurogenetics and Neuroinflammation, Imagine Institute, INSERM UMR1163, Paris, France.
Article Synopsis
- Hereditary C1q deficiency (C1QDef) is a rare genetic disorder that disrupts the complement system and can cause symptoms similar to systemic lupus erythematosus (SLE).
- A study of 12 genetically confirmed C1QDef patients showed elevated expression of interferon-stimulated genes and high levels of interferon alpha in their blood and cerebrospinal fluid, indicating significant immune dysfunction.
- Treatment with Janus-kinase inhibitors had mixed results, with one patient improving while others continued to struggle with their condition, highlighting the complexity of managing C1QDef.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!