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Binding and functional properties of hexocyclium and sila-hexocyclium derivatives to muscarinic receptor subtypes.
Br J Pharmacol
June 1994
Department of Biochemistry and Nutrition, Medical School, Université Libre de Bruxelles, Belgium.
1. We have compared the binding properties of several hexocyclium and sila-hexocyclium derivatives to muscarinic M1 receptors (in rat brain, human neuroblastoma (NB-OK 1) cells and calf superior cervical ganglia), rat heart M2 receptors, rat pancreas M3 receptors and M4 receptors in rat striatum, with their functional antimuscarinic properties in rabbit vas deferens (M1/M4-like), guinea-pig atria (M2), and guinea-pig ileum (M3) muscarinic receptors. 2.
View Article and Find Full Text PDFo-Methoxy-sila-hexocyclium: a new quaternary M1-selective muscarinic antagonist.
Eur J Pharmacol
June 1988
Department of Pharmacology, University of Frankfurt, F.R.G.
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