The present study used quantitative and qualitative methods to investigate contextual factors and motivations associated with emerging adults' electronic aggression victimization and perpetration with friends and dating partners. Participants ( = 226) reported online about electronic aggression occurrence and motivations, family risk, support from friends, and emotion regulation. Males reported more victimization than perpetration overall, whereas females reported more victimization than perpetration only with friends. Jealousy/insecurity emerged as the most common motivation for electronic perpetration; second most common was humor for males and negative emotion for females. Overall, risky family environment was associated with electronic aggression; yet, support from friends and emotion regulation each moderated this association. Discussion addresses potential miscommunications that can occur in electronic communication and the need to look at the interplay between in-person and online interactions.
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http://dx.doi.org/10.1177/2167696813490159 | DOI Listing |
Eur J Pharm Biopharm
January 2025
Late diagnosis is one of the major obstacles for the treatment of breast cancer which can be overcome with a system offering sensitive imaging and selective therapeutic effect. In this study, we developed a "dark-bright" multifunctional drug delivery system bringing real-time imaging and non-invasive therapy together. Theranostic ability of the system was delivered by Verteporfin (VP), serving as a fluorescence probe and a photosensitizer.
View Article and Find Full Text PDFBiochim Biophys Acta Mol Cell Res
January 2025
Biomedical Sciences Program, Department of Life Sciences, School of Sciences, European University Cyprus, Nicosia, Cyprus; Cancer Metastasis and Adhesion Group, Basic and Translational Cancer Research Center (BTCRC), Nicosia, Cyprus. Electronic address:
Colorectal cancer (CRC) ranks second in mortality worldwide while metastasis accounts for most CRC-related deaths. Thus, understanding cell migration, a crucial step in metastasis, is imperative for developing new therapies. Growth Differentiation Factor-15 (GDF15), a member of the Transforming Growth Factor β superfamily, is overexpressed in CRC and promotes metastasis with a so far unknown mechanism.
View Article and Find Full Text PDFNeuron
January 2025
Department of Pathology and Cell Biology, Irving Cancer Research Center, Columbia University Irving Medical Center, New York, NY 10032, USA; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY 10032, USA. Electronic address:
Gliomas are aggressive neoplasms that diffusely infiltrate the brain and cause neurological symptoms, including cognitive deficits and seizures. Increased mTOR signaling has been implicated in glioma-induced neuronal hyperexcitability, but the molecular and functional consequences have not been identified. Here, we show three types of changes in tumor-associated neurons: (1) downregulation of transcripts encoding excitatory and inhibitory postsynaptic proteins and dendritic spine development and upregulation of cytoskeletal transcripts via neuron-specific profiling of ribosome-bound mRNA, (2) marked decreases in dendritic spine density via light and electron microscopy, and (3) progressive functional alterations leading to neuronal hyperexcitability via in vivo calcium imaging.
View Article and Find Full Text PDFHorm Behav
January 2025
School of Biological and Environmental Sciences, Liverpool John Moores University, Byrom Street, Liverpool, L3 3AF, UK. Electronic address:
Within dominance hierarchies, individuals must interact in a rank-appropriate manner, thus behavior and its underlying neural mechanisms must change with social status. One such potential neural mechanism is arginine vasotocin (AVT), a nonapeptide which has been implicated in the regulation of dominance and aggression across vertebrate taxa. We investigated the relationship between social status, dominance-related behaviors, and vasotocin neuron counts in daffodil cichlids (Neolamprologus pulcher).
View Article and Find Full Text PDFAnn Diagn Pathol
January 2025
Department of Pathology, Jichi Medical University, 3311-1, Yakushiji, Shimotsuke, Tochigi, Japan.
The tumor microenvironment is highly heterogeneous and consists of neoplastic cells and diverse stromal components, including fibroblasts, endothelial cells, pericytes, immune cells, local and bone marrow-derived stromal stem and progenitor cells, and the surrounding extracellular matrix. Although the significance of p16 and p53 has been reported in various tumor types, their involvement in the stromal cells of oral squamous cell carcinoma (OSCC) remains unclear. We performed immunohistochemical analyses of p16 and p53 expression in OSCC samples, Of the 116 samples, 74 showed p16-positive stromal cells, and 33 showed p53-positive stromal cells.
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