Ferroptosis is a cell death modality triggered by excessive lipid peroxidation. Two recent studies (Zou et al., 2020; Cui et al., 2021) not only reveal critical roles of ether-linked phospholipids as an additional source for providing polyunsaturated fatty acid-containing phospholipids in driving ferroptosis but also suggest a context-dependent role of TMEM189-mediated vinyl-ether phospholipid (plasmalogen) synthesis in ferroptosis.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8453040 | PMC |
| http://dx.doi.org/10.1016/j.jgg.2021.05.003 | DOI Listing |
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