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Frailty and invasive management of NSTEACS: lights and shadows. Response.
Rev Esp Cardiol (Engl Ed)
December 2024
Servicio de Cardiología, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain.
Corneal and intraocular pressure changes associated to the circadian rhythms: a narrative review.
Int J Ophthalmol
October 2024
Department of Optics, Pharmacology and Anatomy, University of Alicante, San Vicente del Raspeig 03690, Alicante, Spain.
Aim: To synthesize the current body of research regarding the diurnal variations in intraocular pressure (IOP) and corneal biomechanical and morphological parameters, highlighting their significance in various eye conditions.
Methods: A comprehensive review of studies on the diurnal variations of IOP and corneal parameters was conducted. Tonometry findings from various studies were assessed, including the Goldmann applanation tonometry (GAT) and non-contact tonometers.
Integrated multimodal cell atlas of Alzheimer's disease.
Nat Neurosci
December 2024
Allen Institute for Brain Science, Seattle, WA, USA.
Alzheimer's disease (AD) is the leading cause of dementia in older adults. Although AD progression is characterized by stereotyped accumulation of proteinopathies, the affected cellular populations remain understudied. Here we use multiomics, spatial genomics and reference atlases from the BRAIN Initiative to study middle temporal gyrus cell types in 84 donors with varying AD pathologies.
View Article and Find Full Text PDFEvolutionary and molecular basis of ADP-ribosylation reversal by zinc-dependent macrodomains.
J Biol Chem
October 2024
Medical Research Council Centre for Medical Mycology at the University of Exeter, University of Exeter, Exeter, UK. Electronic address:
Dynamic ADP-ribosylation signaling is a crucial pathway that controls fundamental cellular processes, in particular, the response to cellular stresses such as DNA damage, reactive oxygen species, and infection. In some pathogenic microbes, the response to oxidative stress is controlled by a SirTM/zinc-containing macrodomain (Zn-Macro) pair responsible for establishment and removal of the modification, respectively. Targeting this defence mechanism against the host's innate immune response may lead to novel approaches to support the fight against emerging antimicrobial resistance.
View Article and Find Full Text PDFCytotoxic T cells drive doxorubicin-induced cardiac fibrosis and systolic dysfunction.
Nat Cardiovasc Res
August 2024
Department of Immunology, Tufts University, Boston, MA, USA.
Doxorubicin, the most prescribed chemotherapeutic drug, causes dose-dependent cardiotoxicity and heart failure. However, our understanding of the immune response elicited by doxorubicin is limited. Here we show that an aberrant CD8 T cell immune response following doxorubicin-induced cardiac injury drives adverse remodeling and cardiomyopathy.
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