AI Article Synopsis
- The study compared how quickly and effectively men starting a dolutegravir-based HIV treatment reached undetectable levels of the virus in seminal plasma versus blood plasma.
- At the beginning, viral loads were higher in blood plasma compared to seminal plasma.
- By week 48, a higher percentage of participants achieved undetectable viral load in seminal plasma (93%) compared to blood plasma (84%), with quicker undetectable levels in seminal plasma (8 weeks) than in blood plasma (24 weeks).
Article Abstract
We compared the proportion of participants achieving first undetectable HIV-1 RNA (VL) in seminal plasma (SP) and blood plasma (BP) in 19 men starting dolutegravir-based regimen at primary HIV infection. At baseline, median VL was 6.5 (interquartile range [IQR], 5.6-7.9) and 4.5 (IQR, 3.5-5.0) log10 copies/mL in BP and SP, respectively. Between baseline and week 48, significantly higher proportion of participants achieved first VL below limit of quantification in SP (93.0%) than in BP (84.2%; P = .008). Time to first undetectable VL was 8 weeks in SP (95% confidence interval [CI], 5.6-10.4) and 24 weeks in BP (95% CI, 14.1-33.9).
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| http://dx.doi.org/10.1093/infdis/jiab336 | DOI Listing |
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