Background: Oral cladribine is an approved disease-modifying drug for the treatment of relapsing multiple sclerosis. In controlled clinical trials as well as in post marketing safety assessments, autoimmune conditions have not yet been reported as a specific side effect of cladribine.

Objective And Results: Here, we report a case of anti-glomerular basement membrane antibody-mediated glomerulonephritis that occurred shortly after the fourth cladribine treatment cycle.

Conclusion: Neurologists should be attentive to the development of secondary autoimmunity in cladribine-treated patients.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8521349PMC
http://dx.doi.org/10.1177/13524585211022719DOI Listing

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